Swales J D, Heagerty A M
Department of Medicine, University of Leicester, UK.
J Hypertens Suppl. 1987 Jul;5(2):S1-5. doi: 10.1097/00004872-198707002-00001.
Study of the vascular renin-angiotensin system can be approached in a number of ways. The capacity of the blood vessel to generate angiotensin II, when exposed to angiotensinogen, immunocytochemical demonstration of renin, the presence of renin mRNA and functional changes attributable to local generation of angiotensin have all been used. Although each of these techniques requires careful and critical examination from the standpoint of specificity and sensitivity, there is now strong evidence for a functionally important system in the arterial wall. The relative importance of uptake and local synthesis and the physiological role of this system, as distinct from the renal renin system, still remains to be elucidated.
对血管肾素-血管紧张素系统的研究可以通过多种方式进行。血管在接触血管紧张素原时生成血管紧张素II的能力、肾素的免疫细胞化学证明、肾素mRNA的存在以及归因于血管紧张素局部生成的功能变化都已被采用。尽管从特异性和敏感性的角度来看，这些技术中的每一种都需要仔细和严格的审查，但现在有强有力的证据表明动脉壁中存在一个功能重要的系统。与肾脏肾素系统不同，摄取和局部合成的相对重要性以及该系统的生理作用仍有待阐明。
