Malatack J J, Schaid D J, Urbach A H, Gartner J C, Zitelli B J, Rockette H, Fischer J, Starzl T E, Iwatsuki S, Shaw B W
Department of Pediatrics, University of Pittsburgh Health Center, PA.
J Pediatr. 1987 Oct;111(4):479-89. doi: 10.1016/s0022-3476(87)80105-1.
Between March 3, 1981, and June 1, 1984, 216 children were evaluated for orthotopic liver transplantation. Of the 216 patients, 117 (55%) had received at least one liver transplant by June 1, 1985. Fifty-five (25%) died before transplantation. The 117 patients who received transplants were grouped according to severity of disease and degree of general decompensation at the time of transplantation. The severity of a patient's medical condition with the possible exception of deep hepatic coma, did not predict outcome following orthotopic liver transplantation. Seventy variables were assessed at the time of the evaluation. Twenty-three of the 70 variables were found to have prognostic significance with regard to death from progressive liver disease before transplantation. These 23 variables were incorporated into a multivariate model to provide a means of determining the relative risk of death among pediatric patients with end-stage liver disease. This information may allow more informed selection of candidates awaiting liver transplantation.
1981年3月3日至1984年6月1日期间，对216名儿童进行了原位肝移植评估。在这216名患者中，到1985年6月1日时，有117名（55%）接受了至少一次肝移植。55名（25%）在移植前死亡。接受移植的117名患者根据移植时疾病的严重程度和全身失代偿程度进行分组。除深度肝昏迷外，患者病情的严重程度并不能预测原位肝移植后的结果。评估时对70个变量进行了评估。发现这70个变量中的23个对于移植前因进行性肝病死亡具有预后意义。这23个变量被纳入一个多变量模型，以提供一种确定终末期肝病儿科患者死亡相对风险的方法。这些信息可能有助于更明智地选择等待肝移植的候选者。
