Atkinson C T, Aikawa M, Rock E P, Marsh K, Andrysiak P M, Campbell G H, Collins W E, Howard R J
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
J Protozool. 1987 Aug;34(3):267-74. doi: 10.1111/j.1550-7408.1987.tb03173.x.
This report describes the fine structure of the erythrocytic stages of Plasmodium malariae. Erythrocytic parasites from a naturally acquired human infection and an experimentally infected chimpanzee were morphologically indistinguishable and structurally similar to other primate malarias. New findings included observations of highly structured arrays of merozoite surface coat proteins in the cytoplasm of early schizonts and on the surface of budding merozoites and the presence of knobs in the membranes of Maurer's clefts. Morphological evidence is presented suggesting that proteins are transported between the erythrocyte surface and intracellular parasites via two routes: one associated with Maurer's clefts for transport of membrane-associated knob material and a second associated with caveolae in the host cell membrane for the import or export of host- or parasite-derived substances through the erythrocyte cytoplasm.
本报告描述了间日疟原虫红细胞内期的精细结构。来自自然感染人类和实验感染黑猩猩的红细胞内寄生虫在形态上无法区分，并且在结构上与其他灵长类疟疾相似。新发现包括在早期裂殖体细胞质中、出芽裂殖子表面观察到裂殖子表面 coat 蛋白的高度结构化阵列，以及在毛氏小体膜中存在隆起。提供了形态学证据，表明蛋白质通过两条途径在红细胞表面和细胞内寄生虫之间运输：一条与毛氏小体相关，用于运输与膜相关的隆起物质；另一条与宿主细胞膜中的小窝相关，用于通过红细胞细胞质进出宿主或寄生虫衍生的物质。
