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医用大麻患者的麻醉考虑因素。

Anesthetic considerations in medical cannabis patients.

机构信息

Department of Anesthesiology, CCM and Pain Relief, Hadassah Hebrew University Hospital.

Bazelet Medical Cannabis Group, Israel.

出版信息

Curr Opin Anaesthesiol. 2020 Dec;33(6):832-840. doi: 10.1097/ACO.0000000000000932.

DOI:10.1097/ACO.0000000000000932
PMID:33093301
Abstract

PURPOSE OF REVIEW

Growing numbers of patients, consuming cannabinoids admitted to surgery, create a challenge to anesthesia providers. This review provides a summary of recent literature related to cannabis and anesthesia, with specific recommendations to the anesthetic management of medical cannabis consumers.

RECENT FINDINGS

At present, cannabis has found its way to public consensus in many countries and is penetrating slower to different medical fields. We relate and discuss recent findings investigating effects of cannabis consumption on the various aspects including perioperative measures, post-operative pain, PONV, cardiovascular stability, and anesthesia monitoring.

SUMMARY

Recent surveys estimate that 10-20% of adult populations have consumed cannabis in the past year. Medical cannabis consumers are a newer group of cannabis users. Anesthesia providers have to update their knowledge on cannabis and possible anesthetic interaction. It is unreasonable to make recommendations that apply to the whole heterogeneous group of cannabis users, but is easier with the more homogenous group of Medical cannabis users, characterized by frequent use and relatively high cannabis doses, combined with good knowledge of administered composition and protocol, as well as adverse and withdrawal effects. Anesthesia providers have to know the effects and modify anesthetic plan accordingly. We provide perioperative anesthetic recommendations related to medical cannabis consumers. Collecting information of the effects of medical cannabis use in perioperative setting will further create a highly useful database for anesthetics in the close future.

摘要

目的综述

越来越多的使用大麻素的患者接受手术,这给麻醉提供者带来了挑战。本文综述了与大麻和麻醉相关的最新文献,为医用大麻使用者的麻醉管理提供了具体建议。

最新发现

目前,大麻已在许多国家得到公众认可,并逐渐渗透到不同的医学领域。我们调查了大麻消费对包括围手术期措施、术后疼痛、术后恶心呕吐、心血管稳定性和麻醉监测在内的各个方面的影响,并对这些发现进行了讨论。

总结

最近的调查估计,10-20%的成年人口在过去一年中使用过大麻。医用大麻使用者是大麻使用者中的一个较新群体。麻醉提供者必须更新他们对大麻和可能的麻醉相互作用的知识。对整个异质的大麻使用者群体提出建议是不合理的,但对于更同质的医用大麻使用者群体来说,情况就容易一些,这些医用大麻使用者的特点是经常使用且大麻剂量相对较高,同时对所使用的成分和方案有较好的了解,以及对不良反应和戒断症状的了解。麻醉提供者必须了解其作用并相应地修改麻醉计划。我们提供了与医用大麻使用者相关的围手术期麻醉建议。在围手术期环境中收集医用大麻使用效果的信息,将在不久的将来进一步为麻醉学创造一个非常有用的数据库。

相似文献

1
Anesthetic considerations in medical cannabis patients.医用大麻患者的麻醉考虑因素。
Curr Opin Anaesthesiol. 2020 Dec;33(6):832-840. doi: 10.1097/ACO.0000000000000932.
2
Positive and Negative Effects of Cannabis and Cannabinoids on Health.大麻及大麻素对健康的正反影响。
Clin Pharmacol Ther. 2019 May;105(5):1139-1147. doi: 10.1002/cpt.1381. Epub 2019 Mar 12.
3
Cannabinoids for Treatment of MS Symptoms: State of the Evidence.大麻素治疗多发性硬化症症状:证据现状。
Curr Neurol Neurosci Rep. 2018 Jun 19;18(8):50. doi: 10.1007/s11910-018-0859-x.
4
Cannabis, Cannabinoids, and Cerebral Metabolism: Potential Applications in Stroke and Disorders of the Central Nervous System.大麻、大麻素与脑代谢:在中风及中枢神经系统疾病中的潜在应用
Curr Cardiol Rep. 2015 Sep;17(9):627. doi: 10.1007/s11886-015-0627-3.
5
Cannabis and Cannabinoids in the Perioperative Period.围手术期的大麻和大麻素。
Anesth Analg. 2024 Jan 1;138(1):16-30. doi: 10.1213/ANE.0000000000006070. Epub 2023 May 13.
6
Introduction to special issue: Therapeutic and abuse-related effects of cannabis and cannabinoids.特刊介绍:大麻和大麻素的治疗和滥用相关作用。
Exp Clin Psychopharmacol. 2019 Aug;27(4):299-300. doi: 10.1037/pha0000308.
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Medical cannabis and cannabinoids in rheumatology: where are we now?医学大麻和大麻素在风湿病学中的应用:我们现在处于什么位置?
Expert Rev Clin Immunol. 2019 Oct;15(10):1019-1032. doi: 10.1080/1744666X.2019.1665997.
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Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective.性别的依赖性大麻和大麻素的影响:转化视角。
Neuropsychopharmacology. 2018 Jan;43(1):34-51. doi: 10.1038/npp.2017.140. Epub 2017 Jul 17.
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Cannabinoids: Medical implications.大麻素:医学意义。
Ann Med. 2016;48(3):128-41. doi: 10.3109/07853890.2016.1145794. Epub 2016 Feb 25.
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Cannabis and Cannabinoids for Chronic Pain.大麻和大麻素治疗慢性疼痛。
Curr Rheumatol Rep. 2017 Oct 5;19(11):67. doi: 10.1007/s11926-017-0693-1.

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The Use of Recreational Cannabis Among Breast Reduction Patients: Characteristics, Complications, and Immediate Postoperative Analgesic Needs.乳房缩小术患者使用消遣性大麻的情况:特征、并发症及术后即刻镇痛需求
Plast Surg (Oakv). 2024 Aug 30:22925503241276549. doi: 10.1177/22925503241276549.
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Potential perioperative cardiovascular outcomes in cannabis/cannabinoid users. A call for caution.
大麻/大麻素使用者围手术期潜在的心血管结局。需谨慎对待。
Front Cardiovasc Med. 2024 Jun 21;11:1343549. doi: 10.3389/fcvm.2024.1343549. eCollection 2024.
4
[Does medicinal cannabis or cannabis consumption have an influence on the perioperative anesthesiological management?].药用大麻或大麻消费对围手术期麻醉管理有影响吗?
Anaesthesiologie. 2023 Sep;72(9):621-626. doi: 10.1007/s00101-023-01314-z. Epub 2023 Jul 13.
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Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.内源性大麻素信号通过谷氨酸能的丘脑背内侧核-前额叶皮质前边缘投射调节术后谵妄。
Front Aging Neurosci. 2022 Dec 1;14:1036428. doi: 10.3389/fnagi.2022.1036428. eCollection 2022.
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Cannabis Cannabinoid Res. 2022 Jun;7(3):328-335. doi: 10.1089/can.2021.0009. Epub 2021 Jul 5.