Area of Pharmacy and Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Salamanca, Salamanca, 37007, Spain.
The Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, 37007, Spain.
Macromol Biosci. 2021 Jan;21(1):e2000269. doi: 10.1002/mabi.202000269. Epub 2020 Oct 22.
Exosomes, a subgroup of extracellular vesicles, are important mediators of long-distance intercellular communication and are involved in a diverse range of biological processes such as the transport of lipids, proteins, and nucleic acids. Researchers, seeing the problems caused by the toxic effects and clearance of synthetic nanoparticles, consider exosomes as an interesting alternative to such nanoparticles in the specific and controlled transport of drugs. In recent years, there have been remarkable advances in the use of exosomes in cancer therapeutics or for treating neurological diseases, among other applications. The objective of this work is to analyze studies focused on exosomes used in drug delivery system, present and future applications in this field of research are discussed based on the results obtained.
外泌体是细胞外囊泡的一个亚群，是长距离细胞间通讯的重要介质，参与多种生物学过程，如脂质、蛋白质和核酸的运输。研究人员发现，合成纳米颗粒的毒性作用和清除问题，促使他们将外泌体视为在药物的特异性和控制运输中替代此类纳米颗粒的有趣选择。近年来，外泌体在癌症治疗或治疗神经疾病等应用中的应用取得了显著进展。本工作的目的是分析专注于用于药物传递系统的外泌体的研究，根据获得的结果讨论该领域研究中外泌体目前和未来的应用。
