Feng Qixiang, Zhang Yu, Fang Yuelin, Kong Xinru, He Zhijing, Ji Jianbo, Yang Xiaoye, Zhai Guangxi
Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
J Drug Target. 2023 Apr;31(4):335-353. doi: 10.1080/1061186X.2022.2162059. Epub 2023 Jan 3.
Extracellular vesicles (EVs) could be produced by most cells and play an important role in disease development. As a subtype of EVs, exosomes exhibit suitable size, rich surface markers and diverse contents, making them more appealing as potential drug carriers. Compared with traditional synthetic nanoparticles, exosomes possess superior biocompatibility and much lower immunogenicity. This work reviewed the most up-to-date research progress of exosomes as carriers for nucleic acids, proteins and small molecule drugs for cancer and inflammation management. The drug loading strategies and potential cellular uptake behaviour of exosomes are highlighted, trying to provide reference for future exosome design and application.
细胞外囊泡（EVs）可由大多数细胞产生，并在疾病发展中发挥重要作用。作为细胞外囊泡的一种亚型，外泌体具有合适的尺寸、丰富的表面标志物和多样的内容物，使其作为潜在的药物载体更具吸引力。与传统的合成纳米颗粒相比，外泌体具有卓越的生物相容性和低得多的免疫原性。本文综述了外泌体作为核酸、蛋白质和小分子药物载体用于癌症和炎症治疗的最新研究进展。重点介绍了外泌体的药物装载策略和潜在的细胞摄取行为，旨在为未来外泌体的设计和应用提供参考。
