Research Lab of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541100, China.
Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541100, China.
Clin Chim Acta. 2020 Dec;511:319-328. doi: 10.1016/j.cca.2020.10.022. Epub 2020 Oct 21.
Vascular calcification (VC), the pathological process of hydroxyapatite mineral deposition in the vascular system, is closely associated with aging, atherosclerotic plaque formation, cardiovascular disease (CVD) and diabetes mellitus (DM). Studies have shown that VC is related to cellular phenotypic changes, extracellular vesicles, disordered calcium and phosphate homeostasis, and an imbalance between inducers and inhibitors of VC. Unfortunately, there is currently no effective preventive or targeted treatment for pathologic condition. The rapid evolution of omics technology (genomics, epigenomics, transcriptomics, proteomics and metabolomics) has provided a novel approach for elucidation of pathophysiologic mechanisms in general and those associated with VC specifically. Here, we review articles published over the last twenty years and focus on the current state, challenges, limitations and future of omics in VC research and clinical practice. Highlighting potential targets based on omics technology will improve our understanding of this pathologic condition and assist in the development of potential treatment options for VC related disease.
血管钙化（VC）是指羟基磷灰石在血管系统中的病理性沉积过程，与衰老、动脉粥样硬化斑块形成、心血管疾病（CVD）和糖尿病（DM）密切相关。研究表明，VC 与细胞表型变化、细胞外囊泡、钙和磷稳态紊乱以及 VC 诱导剂和抑制剂之间的失衡有关。不幸的是，目前对于这种病理状况还没有有效的预防或靶向治疗方法。组学技术（基因组学、表观基因组学、转录组学、蛋白质组学和代谢组学）的快速发展为阐明一般生理病理机制以及与 VC 相关的机制提供了一种新方法。在这里，我们回顾了过去二十年发表的文章，重点介绍了组学在 VC 研究和临床实践中的现状、挑战、局限性和未来。基于组学技术突出潜在靶点将有助于我们更好地理解这种病理状况，并有助于开发针对 VC 相关疾病的潜在治疗方法。
