Köpf-Maier P
Institut für Anatomie, Freien Universität, Berlin-Dahlem.
Naturwissenschaften. 1987 Aug;74(8):374-82. doi: 10.1007/BF00405465.
Non-platinum-group metal antitumor agents are represented by inorganic and organometallic compounds which contain either main-group metals such as gallium, germanium, and tin, or transition metals such as titanium, vanadium, iron, copper, and gold. Their antiproliferative properties have been detected during the past years, the spectrum of antitumor activity not being identical with that of cytostatic platinum complexes. In the case of germanium complexes, the antitumor activity is obviously not based on direct cytotoxic effects, but on host-mediated immunopotentiating mechanisms. The toxic properties of most non-platinum-group metal antitumor agents differ fundamentally from those of platinum compounds. Thus, non-platinum-group metal antitumor agents may open new perspectives for the clinical therapy of human malignancies.
非铂族金属抗肿瘤剂以无机和有机金属化合物为代表，这些化合物包含主族金属（如镓、锗和锡）或过渡金属（如钛、钒、铁、铜和金）。在过去几年中已检测到它们的抗增殖特性，其抗肿瘤活性谱与细胞抑制性铂配合物的不同。就锗配合物而言，其抗肿瘤活性显然不是基于直接的细胞毒性作用，而是基于宿主介导的免疫增强机制。大多数非铂族金属抗肿瘤剂的毒性特性与铂化合物的根本不同。因此，非铂族金属抗肿瘤剂可能为人类恶性肿瘤的临床治疗开辟新的前景。
