Klapötke T
Department of Chemistry, University of New Brunswick, Fredericton, Canada.
Biol Met. 1988;1(2):69-76. doi: 10.1007/BF01138064.
The chemical aspects of organometallic bismuth(III) compounds are discussed with respect to the stability of the metal-carbon sigma bond, their low dipole moments, and the limited solubility of these complexes in hydrophilic solvents. A new Bi heterocycle, which is of potential interest in terms of stability and solution behaviour, was shown to exist as an intermediate under the conditions in the mass spectrometer. Although generally bismuth organic compounds are extremely toxic, in the 1970s they became important as biocides and this is still being investigated. They have also been discussed as irritation causing chemical warfare agents. While their application in chemotherapy never became very widespread because antibiotics were discovered, in the last few years the antitumor activity of some derivatives has been reported.
本文从金属-碳σ键的稳定性、低偶极矩以及这些配合物在亲水性溶剂中的有限溶解度等方面讨论了有机金属铋（III）化合物的化学性质。一种新的铋杂环化合物，在稳定性和溶液行为方面具有潜在的研究价值，已被证明在质谱仪条件下作为中间体存在。尽管铋有机化合物通常具有极高的毒性，但在20世纪70年代它们作为杀菌剂变得很重要，目前仍在对此进行研究。它们也被作为引起刺激的化学战剂进行讨论。虽然由于抗生素的发现，它们在化疗中的应用从未非常广泛，但在过去几年中，已经报道了一些衍生物的抗肿瘤活性。
