Inoue A, Tsukada N, Koh C S, Yanagisawa N
Department of Medicine (Neurology), Shinshu University, School of Medicine, Matsumoto, Japan.
Neurology. 1987 Oct;37(10):1663-6. doi: 10.1212/wnl.37.10.1663.
We studied a patient with chronic relapsing polyneuropathy associated with immune complexes of hepatitis B virus. There were cycles of remission and exacerbation in parallel with liver dysfunction. Immunofluorescent deposits of hepatitis B antigen, immunoglobulin, and C3 component were detected in the vasa nervorum. Ultrastructural study revealed electron-dense deposits that might have been immune complexes composed of hepatitis B virus, both around the endoneural capillary and in the endoneurium. Immune complexes composed of hepatitis B virus may play a role in the pathogenesis of chronic relapsing polyneuropathy.
我们研究了一名患有与乙型肝炎病毒免疫复合物相关的慢性复发性多神经病的患者。病情存在缓解和加重的周期，与肝功能障碍平行。在神经血管中检测到乙型肝炎抗原、免疫球蛋白和C3成分的免疫荧光沉积物。超微结构研究显示，在内皮毛细血管周围和神经内膜中均有电子致密沉积物，可能是由乙型肝炎病毒组成的免疫复合物。由乙型肝炎病毒组成的免疫复合物可能在慢性复发性多神经病的发病机制中起作用。
