Jiang Nengzhi, Xu Jiahua, Li Xinying, Wang Yanyu, Zhuang Liping, Qin Shaozheng
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; School of Psychology, Weifang Medical University, Weifang, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China; Chinese Institute for Brain Research, Beijing, China.
Biol Psychiatry. 2021 Mar 15;89(6):560-569. doi: 10.1016/j.biopsych.2020.08.002. Epub 2020 Aug 7.
The synergic interaction of risk genes and environmental factors has been thought to play a critical role in mediating emotion-related brain circuitry function and dysfunction in depression and anxiety disorders. Little, however, is known regarding neurodevelopmental bases underlying how maternal negative parenting affects emotion-related brain circuitry linking to adolescent internalizing symptoms and whether this neurobehavioral association is heritable during adolescence.
The effects of maternal parenting on amygdala-based emotional circuitry and internalizing symptoms were examined by using longitudinal functional magnetic resonance imaging among 100 monozygotic twins and 78 dizygotic twins from early adolescence (age 13 years) to mid-adolescence (age 16 years). The mediation effects among variables of interest and their heritability were assessed by structural equation modeling and quantitative genetic analysis, respectively.
Exposure to maternal negative parenting was positively predictive of stronger functional connectivity of the amygdala with the ventrolateral prefrontal cortex. This neural pathway mediated the association between negative parenting and adolescent depressive symptoms and exhibited moderate heritability (21%).
These findings highlight that maternal negative parenting in early adolescence is associated with the development of atypical amygdala-prefrontal connectivity in relation to internalizing depressive symptoms in mid-adolescence. Such abnormality of emotion-related brain circuitry is heritable to a moderate degree.
风险基因与环境因素的协同相互作用被认为在介导抑郁和焦虑症中与情绪相关的脑回路功能及功能障碍方面起着关键作用。然而，关于母亲不良养育方式如何影响与青少年内化症状相关的情绪相关脑回路的神经发育基础，以及这种神经行为关联在青少年期是否具有遗传性，人们所知甚少。
通过对100对同卵双胞胎和78对异卵双胞胎从青春期早期（13岁）到青春期中期（16岁）进行纵向功能磁共振成像，研究母亲养育方式对杏仁核相关情绪回路和内化症状的影响。分别通过结构方程模型和定量遗传分析评估感兴趣变量之间的中介效应及其遗传性。
母亲不良养育方式的暴露正向预测杏仁核与腹外侧前额叶皮质更强的功能连接。这条神经通路介导了不良养育方式与青少年抑郁症状之间的关联，并表现出中等程度的遗传性（21%）。
这些发现突出表明，青春期早期母亲的不良养育方式与青春期中期与内化抑郁症状相关的非典型杏仁核 - 前额叶连接的发展有关。这种与情绪相关的脑回路异常具有中等程度的遗传性。
