Konofsky K, Naumann G O, Guggenmoos-Holzmann I
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg, West Germany.
Ophthalmology. 1987 Jul;94(7):875-80. doi: 10.1016/s0161-6420(87)33543-2.
The lens epithelium of the human eye obviously plays a crucial role in the pathogenesis of primary and secondary cataracts. Four hundred nine flat preparations of human lens epithelium attached to the anterior capsule, obtained during surgical extracapsular cataract extraction (ECCE), were studied. Of these, 197 proved to be suitable for quantitative cell density determination and 93 for counting of the Barr bodies (sex chromatin). Barr bodies are, on the average, found in 54% of the lens epithelial cell nuclei of female patients and in 8% of male patients (P less than 0.001). The median for the cell density of all preparations was 4382 epithelial cells/mm2. Lens epithelium of patients exceeding 50 years of age showed a lower cell density than epithelium of younger patients (P less than 0.05), and, surprisingly, epithelium of females showed a significantly higher density than that of male patients (P less than 0.01). With increasing cortex involvement of the cataracts, a tendency towards a decrease of epithelial cells was noted.
人眼晶状体上皮细胞显然在原发性和继发性白内障的发病机制中起着关键作用。对在白内障囊外摘除术（ECCE）过程中获取的409份附着于前囊的人晶状体上皮细胞扁平标本进行了研究。其中，197份标本适合用于定量细胞密度测定，93份适合用于巴氏小体（性染色质）计数。平均而言，在女性患者的晶状体上皮细胞核中，54%可发现巴氏小体，而在男性患者中这一比例为8%（P<0.001）。所有标本的细胞密度中位数为4382个上皮细胞/mm²。50岁以上患者的晶状体上皮细胞密度低于年轻患者（P<0.05），令人惊讶的是，女性的上皮细胞密度显著高于男性患者（P<0.01）。随着白内障皮质受累程度增加，观察到上皮细胞有减少的趋势。
