Research Institute of Human Morphology, Moscow, Russia.
Bull Exp Biol Med. 2020 Oct;169(6):825-830. doi: 10.1007/s10517-020-04989-1. Epub 2020 Oct 24.
The morphological and functional peculiarities of the immune system are studied in adult male and female Wistar rats with high and low hypoxic resistance. Sex-specific differences in the subpopulation composition of the peripheral blood lymphocytes, not depending on the hypoxic resistance of animals, are detected: the males have lower absolute counts of T helpers and higher percentage of regulatory T cells than the females in the diestrus phase. Comparison of the morphofunctional status of the immune system in male and female (diestrus) rats with high resistance to hypoxia has shown a better developed subcapsular zone of the thymus, higher levels of anti-inflammatory cytokine TGF-β, and lower absolute counts of cytotoxic T lymphocytes in the peripheral blood in the males. Males with low hypoxic resistance have higher counts of phase II thymic bodies in comparison with low-resistant females. Hence, morphofunctional differences in the immune system of male and female rats with different hypoxic resistance are detected, which can determine the course of inflammatory diseases.
研究了高、低缺氧抗性雄性和雌性 Wistar 大鼠免疫系统的形态和功能特点。检测到外周血淋巴细胞亚群组成的性别特异性差异，这些差异不依赖于动物的缺氧抗性：在动情期，雄性的 T 辅助细胞绝对计数较低，调节性 T 细胞的百分比较高。比较高缺氧抗性雄性和雌性（动情期）大鼠的免疫系统形态和功能状态表明，雄性的胸腺被膜下区发育更好，抗炎细胞因子 TGF-β 水平更高，外周血中细胞毒性 T 淋巴细胞的绝对计数更低。与低抗性雌性相比，低抗性雄性的 II 期胸腺小体计数更高。因此，检测到不同缺氧抗性雄性和雌性大鼠免疫系统的形态和功能差异，这可以决定炎症性疾病的进程。
