Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cancer Prevention Fellowship Program, Division of Cancer Prevention, Healthcare Delivery Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Cancer Causes Control. 2021 Jan;32(1):103-107. doi: 10.1007/s10552-020-01354-5. Epub 2020 Oct 24.
Women with a first-degree family history of breast cancer (FHBC) are sometimes advised to initiate screening mammography when they are 10 years younger than the age at which their youngest relative was diagnosed, despite a lack of unambiguous evidence that this is an effective strategy. It is unknown how often this results in women initiating screening earlier (< 40 years) than screening guidelines recommend for average-risk women.
We examined screening initiation age by FHBC and age at diagnosis of the youngest relative using data collected by the Breast Cancer Surveillance Consortium on 74,838 first screening mammograms performed between 1996 and 2016.
Of the 74,838 women included in the study, nearly 9% reported a FHBC. Approximately 16.8% of women who initiated mammography before 40 years reported a FHBC. More women with a FHBC than without initiated screening < 40 years (48% vs. 23%, respectively). Among women with a FHBC who initiated screening < 40 years, 65% were 10 years younger than the age at which their relative was diagnosed.
Women with a first-degree relative diagnosed with breast cancer were more likely to start screening before 40 years than women reporting no FHBC, especially if their relative was diagnosed before 50 years.
有一级亲属乳腺癌家族史（FHBC）的女性有时会被建议比家族中最年轻的患者诊断年龄提前 10 岁开始进行筛查性乳房 X 光检查，尽管缺乏明确证据表明这是一种有效的策略。目前尚不清楚这种情况导致女性提前（<40 岁）开始筛查的频率有多高，与平均风险女性的筛查指南建议相比。
我们使用乳腺癌监测联盟在 1996 年至 2016 年间收集的 74838 份首次筛查性乳房 X 光检查的数据，根据 FHBC 和最年轻亲属的诊断年龄来检查筛查起始年龄。
在研究中纳入的 74838 名女性中，近 9%的女性报告有 FHBC。在<40 岁开始进行乳房 X 光检查的女性中，约 16.8%的女性报告有 FHBC。与没有 FHBC 的女性相比，有 FHBC 的女性更有可能在<40 岁开始进行筛查（分别为 48%和 23%）。在有 FHBC 且<40 岁开始进行筛查的女性中，有 65%的女性比其亲属诊断年龄小 10 岁。
与没有 FHBC 的女性相比，有一级亲属被诊断患有乳腺癌的女性更有可能在 40 岁之前开始进行筛查，尤其是当她们的亲属在 50 岁之前被诊断出患有乳腺癌时。
