含硫醇配体的二亚硝酰基铁配合物作为亚硝鎓阳离子供体可抑制病毒感染（假说）。
Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis).
作者信息
Vanin A F
机构信息
Semenov Institute of Chemical Physics, 119334 Moscow, Russia.
Institute of Regenerative Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
出版信息
Biophysics (Oxf). 2020;65(4):698-702. doi: 10.1134/S0006350920040260. Epub 2020 Oct 19.
Abstract
The appropriateness of verification of the possible antiviral effect of dinitrosyl iron complexes with thiol-containing ligands as donors of nitrosonium cations (NO) is argued. There is reason to hope that treatment of the human respiratory tract and lungs with sprayed solutions of dinitrosyl iron complexes with glutathione or N-acetylcysteine (NAC) as NO donors during COVID-19 infection can initiate S-nitrosylation of cellular proteases and thereby suppress viral infection.
摘要
有人认为验证含硫醇配体的二亚硝基铁配合物作为亚硝鎓阳离子（NO）供体可能具有的抗病毒作用是否合适是有必要的。有理由希望，在新冠病毒感染期间，用含有谷胱甘肽或N-乙酰半胱氨酸（NAC）作为NO供体的二亚硝基铁配合物的喷雾溶液治疗人类呼吸道和肺部，可以引发细胞蛋白酶的S-亚硝基化，从而抑制病毒感染。
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