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寻常狼疮及瘰疬性苔藓伴播散性结核病

Lupus Vulgaris and Lichen Scrofulosorum with Disseminated Tuberculosis.

作者信息

Okoh Nnenna Uzunma, Nnaji T, Onyekonwu Chinwe L, Emeka Chika Mary

机构信息

Department of Internal Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Abakaliki, Ebonyi State, Nigeria.

Department of Internal Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria.

出版信息

Niger Med J. 2020 May-Jun;61(3):169-172. doi: 10.4103/nmj.NMJ_135_19. Epub 2020 Jul 4.

Abstract

Cutaneous tuberculosis (CTB) represents only 1%-2% of extrapulmonary forms of tuberculosis (TB). CTB can present in the isolation or coexist with pulmonary and disseminated forms of TB. Pathologically confirmed lupus vulgaris (LV) coexisting with lichen scrofulosorum with disseminated TB is presented and discussed. A 12-year-old boy presented with 2 years history of slowly progressive facial plaque and multiple skin colored papules on the neck. Tuberculin skin test was positive with a reading of > 20 mm. Histopathology revealed ulcerated areas with impetiginisation and keratopurulent debris. The entire skin showed pseudoepitheliomatous hyperplasia with numerous granulomas in the superficial dermis consisting of Langhans-type multinucleated macrophages. Lesions responded to anti-tuberculosis therapy (ATT) with residual facial scar. LV and lichen scrofulosurum are two forms of CTB which rarely occurs together. This case is being presented to highlight the occurrence of this rare presentation and the need to institute ATT to prevent scarring.

摘要

皮肤结核(CTB)仅占肺外结核(TB)形式的1%-2%。CTB可单独出现,也可与肺结核及播散性结核同时存在。本文展示并讨论了经病理证实的寻常狼疮(LV)与瘰疬性苔藓合并播散性结核共存的情况。一名12岁男孩,有2年缓慢进展的面部斑块及颈部多个肤色丘疹病史。结核菌素皮肤试验阳性,读数>20mm。组织病理学显示有溃疡区域伴脓疱形成及角化脓性碎屑。整个皮肤表现为假上皮瘤样增生,浅表真皮层有大量由朗汉斯型多核巨噬细胞组成的肉芽肿。病变对抗结核治疗(ATT)有反应,面部遗留瘢痕。LV和瘰疬性苔藓是CTB的两种形式,很少同时发生。本文展示此病例是为了突出这种罕见表现的发生情况以及进行ATT以预防瘢痕形成的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07f/7547755/1a63cff0041c/NMJ-61-169-g001.jpg

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