Arai I, Hirose H, Muramatsu M, Aihara H
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Physiol Behav. 1987;40(3):357-61. doi: 10.1016/0031-9384(87)90059-x.
Effects of restraint and water-immersion stress (RWIS) and of insulin injection on gastric acid secretion were investigated in relation to blood glucose levels and to brain glucose uptake in rats. Venous blood glucose levels (VBG) were significantly increased while arterial blood glucose level (ABG) was slightly increased by RWIS. In contrast, ABG and VBG were significantly decreased by administration of insulin; the decrease in ABG was greater than that in VBG. Glucose uptake into the brain, calculated from the ABG-VBG, was significantly decreased both by RWIS loading and by insulin administration. The uptake of [14C] 2-deoxy-D-glucose [( 14C]-2DG) into the brain was also significantly decreased in RWIS-loaded or insulin-treated rats. Gastric acid output was significantly increased both by RWIS loading and by insulin administration. The increased acid output paralleled the decrease of glucose uptake into the brain in RWIS-loaded and insulin-treated rats. Results suggest that RWIS-induced gastric acid secretion is regulated by brain glucose uptake and that this gastric acid secretion is a hypothalamic neuron-mediated event as is insulin-stimulated gastric acid secretion.
研究了束缚和水浸应激（RWIS）以及胰岛素注射对大鼠胃酸分泌的影响，并将其与血糖水平和脑葡萄糖摄取相关联。束缚和水浸应激使静脉血糖水平（VBG）显著升高，而动脉血糖水平（ABG）略有升高。相反，胰岛素给药使ABG和VBG显著降低；ABG的降低幅度大于VBG。根据ABG-VBG计算得出的脑葡萄糖摄取量，在施加束缚和水浸应激以及胰岛素给药后均显著降低。在施加束缚和水浸应激的大鼠或接受胰岛素治疗的大鼠中，[14C]2-脱氧-D-葡萄糖（[14C]-2DG）的脑摄取也显著降低。束缚和水浸应激以及胰岛素给药均使胃酸分泌显著增加。在施加束缚和水浸应激的大鼠以及接受胰岛素治疗的大鼠中，胃酸分泌增加与脑葡萄糖摄取减少平行。结果表明，束缚和水浸应激诱导的胃酸分泌受脑葡萄糖摄取调节，且这种胃酸分泌与胰岛素刺激的胃酸分泌一样，是下丘脑神经元介导的事件。
