Arai I, Muramatsu M, Aihara H
Jpn J Pharmacol. 1986 Apr;40(4):501-4. doi: 10.1254/jjp.40.501.
The effect of water temperature during restraint and water-immersion stress (RWIS) on gastric regional blood flow, acid secretion and ulcer formation were compared to those of restraint stress (RS) alone in rats. RS had no effect on the gastric regional blood flow. In contrast, the gastric regional blood flow was significantly decreased by RWIS. A water temperature dependent reduction of gastric regional blood flow induced by RWIS was observed between 20 degrees C and 30 degrees C. The decrease in gastric regional blood flow for RWIS rats was related to a lowering of the body temperature, which almost coincided with the temperature of water for the immersion. The gastric acid output was not influenced by RS. However, RWIS significantly increased the gastric acid output. The temperature of water in order of increasing acid output induced by RWIS was 25 degrees C greater than 30 degrees C greater than 20 degrees C. Little ulcer formation was found in RS rats, while exposure to RWIS caused marked ulceration. The temperature of water in order of severity of ulceration by RWIS was 25 degrees C greater than 20 degrees C greater than 30 degrees C. The severity of ulceration was not related to the decrease in gastric regional blood flow or increase of acid output, but was correlated to the ratio of the gastric blood flow/the acid output. These findings suggest that the decrease of gastric regional blood flow is in good agreement with the fall of body temperature, and the combined effects of the gastric blood flow and the acid secretion are involved in the ulceration caused by RWIS.
将束缚和水浸应激（RWIS）期间的水温对大鼠胃局部血流量、胃酸分泌和溃疡形成的影响与单独束缚应激（RS）的影响进行了比较。RS对胃局部血流量没有影响。相比之下，RWIS显著降低了胃局部血流量。在20摄氏度至30摄氏度之间观察到RWIS诱导的胃局部血流量随水温降低。RWIS大鼠胃局部血流量的减少与体温降低有关，体温降低几乎与浸泡水的温度一致。胃酸分泌不受RS影响。然而，RWIS显著增加了胃酸分泌。RWIS诱导胃酸分泌增加的水温顺序为25摄氏度大于30摄氏度大于20摄氏度。RS大鼠中几乎没有溃疡形成，而暴露于RWIS会导致明显的溃疡。RWIS导致溃疡严重程度的水温顺序为25摄氏度大于20摄氏度大于30摄氏度。溃疡的严重程度与胃局部血流量的减少或胃酸分泌的增加无关，而是与胃血流量/胃酸分泌的比值相关。这些发现表明，胃局部血流量的减少与体温下降高度一致，胃血流量和胃酸分泌的综合作用参与了RWIS引起的溃疡形成。
