Klimek Mateusz, Radosz Patrycja, Lemm Magdalena, Szanecki Wojciech, Dudek Aleksandra, Pokładek Sandra, Piwowarczyk Maria, Poński Michał, Cichoń Bartosz, Kajor Maciej, Witek Andrzej
Department of Gynaecology, Medical University of Silesia, Katowice, Poland.
Students' Scientific Society, Department of Gynaecology, Medical University of Silesia, Katowice, Poland.
Prz Menopauzalny. 2020 Sep;19(3):140-143. doi: 10.5114/pm.2020.99578. Epub 2020 Oct 2.
Leydig cell ovarian tumors constitute not only a medical problem for clinicians but also a social problem - which is why women with symptoms of hirsutism relatively quickly contact physicians for medical consultation. Leydig cell ovarian tumor is a rare sex cord-gonadal stromal tumor which constitutes less than 0.5% of ovarian tumors. These cancers appear at all ages but the majority of the cases concern women in the perimenopause. In the majority of cases (70-85%), the growth is accompanied by androgen secretion, together with virilization and hirsutism. The presence of hormonally active ovarian cancers should be suspected in cases of rapidly growing symptoms of masculinization, especially when the level of free testosterone in the blood exceeds the upper limit for the given age more than three times. In diagnosing postmenopausal hyperandrogenism, it is necessary to take into account hormonally active ovarian tumors, as well as adrenal cancers. It is important to exclude other causes of hyperandrogenism, e.g. endocrinopathies (acromegaly or hypothyroidism), or iatrogenic and idiopathic factors. In order to make the diagnosis and implement the proper treatment method faster, an interdisciplinary team of physicians specializing in endocrinology, gynecology and oncology is crucial. This paper contains a study of two cases concerning Leydig cell ovarian tumors in women of postmenopausal age with symptoms of masculinization and hirsutism.
睾丸间质细胞瘤不仅给临床医生带来医学问题，也是一个社会问题——这就是为什么出现多毛症状的女性会相对较快地联系医生进行医疗咨询。睾丸间质细胞瘤是一种罕见的性索-性腺间质肿瘤，占卵巢肿瘤的比例不到0.5%。这些癌症在各年龄段均可出现，但大多数病例涉及围绝经期女性。在大多数病例（70-85%）中，肿瘤生长伴随着雄激素分泌，同时伴有男性化和多毛症状。在出现快速进展的男性化症状时，应怀疑存在具有激素活性的卵巢癌，尤其是当血液中游离睾酮水平超过特定年龄上限三倍以上时。在诊断绝经后高雄激素血症时，有必要考虑具有激素活性的卵巢肿瘤以及肾上腺癌。排除高雄激素血症的其他原因，如内分泌疾病（肢端肥大症或甲状腺功能减退症）或医源性和特发性因素很重要。为了更快地做出诊断并实施适当的治疗方法，由内分泌学、妇科和肿瘤学专家组成的跨学科医生团队至关重要。本文包含对两例绝经后出现男性化和多毛症状的女性睾丸间质细胞瘤病例的研究。
