Diez Lisa, Wegmann Susanne
German Center for Neurodegenerative Diseases, Berlin, Germany.
Front Neurol. 2020 Sep 25;11:1056. doi: 10.3389/fneur.2020.01056. eCollection 2020.
Tau is a cytosolic microtubule binding protein that is highly abundant in the axons of the central nervous system. However, alternative functions of tau also in other cellular compartments are suggested, for example, in the nucleus, where interactions of tau with specific nuclear entities such as DNA, the nucleolus, and the nuclear envelope have been reported. We would like to review the current knowledge about tau-nucleus interactions and lay out possible neurotoxic mechanisms that are based on the (pathological) interactions of tau with the nucleus.
tau是一种胞质微管结合蛋白，在中枢神经系统的轴突中高度丰富。然而，有研究表明tau在其他细胞区室中也具有其他功能，例如在细胞核中，已有报道称tau与特定的核实体如DNA、核仁及核膜存在相互作用。我们希望回顾目前关于tau与细胞核相互作用的知识，并阐述基于tau与细胞核的（病理）相互作用可能产生的神经毒性机制。
