肺痹方通过调控BRP39/IL-17和TGF1/Smad3信号通路减轻博来霉素诱导的小鼠肺纤维化

Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGF1/Smad3 Signal Pathways.

作者信息

Wang Wei, Liu Zhaoheng, Niu Jie, Yang Haojie, Long Qi, Liu Haoge, Gu Xiaofeng, Jiao Yang

机构信息

Respiratory Department, Chongqing Traditional Chinese Medicine Hospital, No. 6 Pan Xi Qi Zhi, Jiangbei District, Chongqing 400021, China.

School of Life Sciences, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Yang Guang Nan Da Jie and Bai Yang Dong Lu, Fangshan District, Beijing 102488, China.

出版信息

Evid Based Complement Alternat Med. 2020 Oct 12;2020:5814658. doi: 10.1155/2020/5814658. eCollection 2020.

Fibrotic remodeling has become the result of many lung diseases, and these disorders can be categorized with known as well as unknown etiologies. Idiopathic pulmonary fibrosis is the most fatal disease among the unknown etiology. TGF1/Smad3 signal pathway plays an important role in lung fibrosis and epithelial regeneration. This study investigated the effects and mechanism of Feibi Recipe (FBR) on pulmonary fibrosis. In this experiment, C57BL/6 mice were used and bleomycin was used to induce the lung injury. Meanwhile, the study showed a significant reduction in pathological response and mediators of inflammation and fibrosis such as IL-6, ICAM-1, IL-13, IL-17, BRP-39, TGF1, Smad3, and Smad7 were identified. Collectively, the FBR appears to attenuate the lung injury and the modeling of fibrosis in mice.