肺损伤、修复和转移中的几丁质酶样蛋白。
Chitinase-like proteins in lung injury, repair, and metastasis.
机构信息
Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520-8056, USA.
出版信息
Proc Am Thorac Soc. 2012 May;9(2):57-61. doi: 10.1513/pats.201112-056MS.
Abstract
This report explains how our studies of asthma and Th2 inflammation led us to investigate the roles of chitinase-like proteins (CLPs) in lung injury and repair and puts forth an overall hypothesis that can explain the roles that these moieties play in biology and a hypothesis regarding the ways that dysregulated CLP expression may contribute to the pathogenesis of a variety of diseases. We test this hypothesis by assessing the contributions of the CLP breast regression protein (BRP)-39 in the pathogenesis of malignant melanoma metastasis to the lung.
摘要
本报告解释了我们对哮喘和 Th2 炎症的研究如何引导我们研究几丁质酶样蛋白 (CLP) 在肺损伤和修复中的作用，并提出了一个总体假设，可以解释这些物质在生物学中的作用，以及关于失调的 CLP 表达可能导致多种疾病发病机制的假设。我们通过评估 CLP 乳腺退化蛋白 (BRP)-39 在恶性黑色素瘤转移到肺部的发病机制中的作用来检验这一假设。
相似文献
1
Chitinase-like proteins in lung injury, repair, and metastasis.肺损伤、修复和转移中的几丁质酶样蛋白。
Proc Am Thorac Soc. 2012 May;9(2):57-61. doi: 10.1513/pats.201112-056MS.
2
The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.几丁质酶样蛋白乳腺退化蛋白 39 和 YKL-40 调节高氧诱导的急性肺损伤。
Am J Respir Crit Care Med. 2010 Oct 1;182(7):918-28. doi: 10.1164/rccm.200912-1793OC. Epub 2010 Jun 17.
3
Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanoma metastasis.几丁质酶3样-1和信号素7a在肺黑色素瘤转移中的作用
Cancer Res. 2015 Feb 1;75(3):487-96. doi: 10.1158/0008-5472.CAN-13-3339. Epub 2014 Dec 15.
4
A novel function for vimentin: the potential biomarker for predicting melanoma hematogenous metastasis.一种中间丝蛋白（波形蛋白）的新功能：预测黑色素瘤血行转移的潜在生物标志物。
J Exp Clin Cancer Res. 2010 Aug 11;29(1):109. doi: 10.1186/1756-9966-29-109.
5
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.乳腺退化蛋白39（BRP-39）/几丁质酶3样蛋白1在Th2和IL-13诱导的组织反应及细胞凋亡中的作用
J Exp Med. 2009 May 11;206(5):1149-66. doi: 10.1084/jem.20081271. Epub 2009 May 4.
6
Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function.几丁质酶样蛋白 Brp-39/YKL-40 调节肾对缺血性损伤的反应，并预测移植物功能延迟。
J Am Soc Nephrol. 2013 Feb;24(2):309-19. doi: 10.1681/ASN.2012060579. Epub 2013 Jan 4.
7
Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation.几丁质酶3样蛋白1调节内脏脂肪堆积和哮喘样Th2炎症。
Am J Respir Crit Care Med. 2015 Apr 1;191(7):746-57. doi: 10.1164/rccm.201405-0796OC.
8
Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models.窖蛋白-1 是临床前黑色素瘤模型中手术后转移的一个风险因素。
Melanoma Res. 2014 Apr;24(2):108-19. doi: 10.1097/CMR.0000000000000046.
9
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.几丁质和几丁质酶/几丁质酶样蛋白在炎症、组织重塑和损伤中的作用。
Annu Rev Physiol. 2011;73:479-501. doi: 10.1146/annurev-physiol-012110-142250.
10
IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses.白细胞介素-13 受体 α2 通过几丁质酶 3 样蛋白 1 诱导的信号转导和效应子反应利用跨膜蛋白 219。
Nat Commun. 2016 Sep 15;7:12752. doi: 10.1038/ncomms12752.
引用本文的文献
1
Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation.最近，几类细胞中几丁质酶 3 样蛋白 1 作为慢性炎症主要影响因子的作用。
Cells. 2024 Apr 14;13(8):678. doi: 10.3390/cells13080678.
2
A Natural CHI3L1-Targeting Compound, Ebractenoid F, Inhibits Lung Cancer Cell Growth and Migration and Induces Apoptosis by Blocking CHI3L1/AKT Signals.一种天然的 CHI3L1 靶向化合物，埃博霉素 F，通过阻断 CHI3L1/AKT 信号通路抑制肺癌细胞生长和迁移并诱导细胞凋亡。
Molecules. 2022 Dec 31;28(1):329. doi: 10.3390/molecules28010329.
3
A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.一种靶向 CHI3L1 的小分子通过阻断 IL-13Rα2 介导的 JNK-AP-1 信号抑制肺癌转移。
Mol Oncol. 2022 Jan;16(2):508-526. doi: 10.1002/1878-0261.13138. Epub 2021 Nov 24.
4
Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGF1/Smad3 Signal Pathways.肺痹方通过调控BRP39/IL-17和TGF1/Smad3信号通路减轻博来霉素诱导的小鼠肺纤维化
Evid Based Complement Alternat Med. 2020 Oct 12;2020:5814658. doi: 10.1155/2020/5814658. eCollection 2020.
5
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer.SNHG12：一种作为人类癌症潜在治疗靶点和生物标志物的长链非编码RNA
Front Oncol. 2019 Sep 18;9:901. doi: 10.3389/fonc.2019.00901. eCollection 2019.
6
Role of genetic variations of - in bronchial asthmatic patients.-的基因变异在支气管哮喘患者中的作用。 （你提供的原文“Role of genetic variations of - ”这里“-”指代不明，以上是按常规理解翻译）
Clin Mol Allergy. 2018 Apr 2;16:9. doi: 10.1186/s12948-018-0086-7. eCollection 2018.
7
Circulating tumor cell interactions with macrophages: implications for biology and treatment.循环肿瘤细胞与巨噬细胞的相互作用：对生物学及治疗的意义
Transl Lung Cancer Res. 2017 Aug;6(4):418-430. doi: 10.21037/tlcr.2017.07.04.
8
Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9.几丁质酶3样蛋白1通过调控S100A9诱导慢性炎症和结肠炎相关癌症期间肠上皮细胞的存活和增殖。
Oncotarget. 2015 Nov 3;6(34):36535-50. doi: 10.18632/oncotarget.5440.
9
YKL-40/CHI3L1 drives inflammation on the road of tumor progression.YKL-40/CHI3L1在肿瘤进展过程中引发炎症。
J Leukoc Biol. 2015 Dec;98(6):931-6. doi: 10.1189/jlb.3VMR0415-142R. Epub 2015 Aug 26.
10
Chitinase-3-like-1/YKL-40 as marker of circulating tumor cells.几丁质酶 3 样蛋白 1/ YKL-40 作为循环肿瘤细胞的标志物。
Transl Lung Cancer Res. 2015 Jun;4(3):287-91. doi: 10.3978/j.issn.2218-6751.2015.04.04.
本文引用的文献
1
Lebrikizumab treatment in adults with asthma.来氟米特治疗成人哮喘。
N Engl J Med. 2011 Sep 22;365(12):1088-98. doi: 10.1056/NEJMoa1106469. Epub 2011 Aug 3.
2
Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema.乳腺反应蛋白-39 在香烟烟雾诱导的炎症和肺气肿发病机制中的作用。
Am J Respir Cell Mol Biol. 2011 Jun;44(6):777-86. doi: 10.1165/rcmb.2010-0081OC. Epub 2010 Jul 23.
3
The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.几丁质酶样蛋白乳腺退化蛋白 39 和 YKL-40 调节高氧诱导的急性肺损伤。
Am J Respir Crit Care Med. 2010 Oct 1;182(7):918-28. doi: 10.1164/rccm.200912-1793OC. Epub 2010 Jun 17.
4
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.乳腺退化蛋白39（BRP-39）/几丁质酶3样蛋白1在Th2和IL-13诱导的组织反应及细胞凋亡中的作用
J Exp Med. 2009 May 11;206(5):1149-66. doi: 10.1084/jem.20081271. Epub 2009 May 4.
5
Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy.几丁质酶3样蛋白1启动子区域的基因变异与特应性相关。
Am J Respir Crit Care Med. 2009 Mar 15;179(6):449-56. doi: 10.1164/rccm.200809-1422OC. Epub 2008 Dec 23.
6
Chitinase 3-Like-1 (CHI3L1): a putative disease marker at the interface of proteomics and glycomics.几丁质酶3样蛋白1（CHI3L1）：蛋白质组学与糖组学交叉领域的一种潜在疾病标志物。
Crit Rev Clin Lab Sci. 2008;45(6):531-62. doi: 10.1080/10408360802334743.
7
YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria.YKL-40是一种炎症和内皮功能障碍的标志物，在1型糖尿病患者中升高，并随蛋白尿水平升高而增加。
Diabetes Care. 2009 Feb;32(2):323-8. doi: 10.2337/dc08-1144. Epub 2008 Oct 28.
8
YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages.YKL-40在慢性阻塞性肺疾病患者中升高，并激活肺泡巨噬细胞。
J Immunol. 2008 Oct 1;181(7):5167-73. doi: 10.4049/jimmunol.181.7.5167.
9
Plasma YKL-40: a BMI-independent marker of type 2 diabetes.血浆YKL-40：一种与体重指数无关的2型糖尿病标志物。
Diabetes. 2008 Nov;57(11):3078-82. doi: 10.2337/db08-0182. Epub 2008 Jul 23.
10
Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein.几丁质酶3样蛋白1通过与细菌几丁质结合蛋白相互作用增强细菌对结肠上皮细胞的黏附。
Lab Invest. 2008 Aug;88(8):883-95. doi: 10.1038/labinvest.2008.47. Epub 2008 May 19.
Zotero 插件