Mercado Mary Evangeline Villa, Huang Kuan-Gen, Lay Zin Mar, Huang Shih-Yin
Department of Obstetrics and Gynecology, N. L. Villa Memorial Medical Center, Lipa, Philippines.
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.
Gynecol Minim Invasive Ther. 2025 Feb 27;14(1):89-93. doi: 10.4103/gmit.gmit_20_24. eCollection 2025 Jan-Mar.
The occurrence of metachronous multiple primary malignancies remains relatively rare; however, its incidence is notably rising. We present the case of a 25-year-old woman who underwent fertility-sparing surgery, followed by chemotherapy for ovarian yolk sac tumor. Three years later, the patient was diagnosed with a large B-cell lymphoma in the cecum. She underwent bowel surgery and received chemotherapy postoperatively. Despite her condition, she was able to conceive spontaneously and had a successful pregnancy after treatment. This report highlights the importance of considering fertility-preserving treatment strategies in young patients and the possibility of spontaneous conception and successful pregnancy even in patients diagnosed with metachronous multiple primary malignancies who underwent extensive surgical procedures and heavily treated with chemotherapy.
异时性多原发性恶性肿瘤的发生仍然相对罕见；然而，其发病率正在显著上升。我们报告一例25岁女性病例，该患者接受了保留生育功能的手术，随后因卵巢卵黄囊瘤接受化疗。三年后，患者被诊断为盲肠大B细胞淋巴瘤。她接受了肠道手术并在术后接受化疗。尽管病情如此，她仍能自然受孕，并在治疗后成功妊娠。本报告强调了在年轻患者中考虑保留生育功能治疗策略的重要性，以及即使是被诊断为异时性多原发性恶性肿瘤且接受了广泛外科手术和强化化疗的患者，仍有自然受孕和成功妊娠的可能性。
