Song Shaochen, Wang Xuejie, Wang Tiejun, Yu Qinghua, Hou Zheyu, Zhu Zhe, Li Rui
Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, China.
Department of Orthopaedic Traumatology, The First Hospital of Jilin University, Changchun, China.
Front Bioeng Biotechnol. 2020 Sep 25;8:590596. doi: 10.3389/fbioe.2020.590596. eCollection 2020.
As a common and frequent clinical disease, peripheral nerve defect has caused a serious social burden, which is characterized by poor curative effect, long course of treatment and high cost. Nerve autografting is first-line treatment of peripheral nerve injuries (PNIs) but can result in loss of function of the donor site, neuroma formation, and prolonged operative time. Nerve guidance conduit (NGC) serves as the most promising alternative to autologous transplantation, but its production process is complicated and it is difficult to effectively combine growth factors and bioactive substances. In recent years, additive manufacturing of NGCs has effectively solved the above problems due to its simple and efficient manufacturing method, and it can be used as the carrier of bioactive substances. This review examines recent advances in additive manufacture of NGCs for PNIs as well as insight into how these approaches could be improved in future studies.
作为一种常见且多发的临床疾病，周围神经缺损已造成严重的社会负担，其特点是疗效不佳、疗程长且费用高。自体神经移植是周围神经损伤（PNIs）的一线治疗方法，但会导致供体部位功能丧失、形成神经瘤以及手术时间延长。神经引导导管（NGC）是自体移植最有前景的替代方法，但其生产过程复杂，难以有效结合生长因子和生物活性物质。近年来，NGC的增材制造因其简单高效的制造方法有效解决了上述问题，并且它可作为生物活性物质的载体。本文综述了用于PNIs的NGC增材制造的最新进展以及对这些方法在未来研究中如何改进的见解。
