用于促进骨坏死骨再生的工程化三维支架

Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis.

作者信息

Zhu Tongtong, Cui Yutao, Zhang Mingran, Zhao Duoyi, Liu Guangyao, Ding Jianxun

机构信息

Department of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, PR China.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.

出版信息

Bioact Mater. 2020 Apr 17;5(3):584-601. doi: 10.1016/j.bioactmat.2020.04.008. eCollection 2020 Sep.

Osteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint destruction, and arthroplasty is eventually required. Enhancement of bone regeneration is a critical management strategy employed in osteonecrosis therapy. Bone tissue engineering based on engineered three-dimensional (3D) scaffolds with appropriate architecture and osteoconductive activity, alone or functionalized with bioactive factors, have been developed to enhance bone regeneration in osteonecrosis. In this review, we elaborate on the ideal properties of 3D scaffolds for enhanced bone regeneration in osteonecrosis, including biocompatibility, degradability, porosity, and mechanical performance. In addition, we summarize the development of 3D scaffolds alone or functionalized with bioactive factors for accelerating bone regeneration in osteonecrosis and discuss their prospects for translation to clinical practice.

骨坏死通常由创伤、糖皮质激素滥用或酗酒引起，是临床骨科中最严重的疾病之一。骨坏死常导致关节破坏，最终需要进行关节置换术。促进骨再生是骨坏死治疗中采用的关键管理策略。基于具有适当结构和骨传导活性的工程化三维（3D）支架的骨组织工程，单独使用或用生物活性因子功能化，已被开发用于增强骨坏死中的骨再生。在这篇综述中，我们阐述了用于增强骨坏死中骨再生的3D支架的理想特性，包括生物相容性、可降解性、孔隙率和机械性能。此外，我们总结了单独使用或用生物活性因子功能化的3D支架在加速骨坏死中骨再生方面的进展，并讨论了它们转化为临床实践的前景。