Jiang Huiquan, Qian Yun, Fan Cunyi, Ouyang Yuanming
College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China.
Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Front Bioeng Biotechnol. 2020 Sep 25;8:582646. doi: 10.3389/fbioe.2020.582646. eCollection 2020.
Peripheral nerve injuries (PNIs) are usually caused by trauma, immune diseases, and genetic factors. Peripheral nerve injury (PNI) may lead to limb numbness, muscle atrophy, and loss of neurological function. Although an abundance of theories have been proposed, very few treatments can effectively lead to complete recovery of neurological function. Autologous nerve transplantation is currently the gold standard. Nevertheless, only 50% of all patients were successfully cured using this method. In addition, it causes inevitable damage to the donor site, and available donor sites in humans are very limited. Tissue engineering has become a research hotspot aimed at achieving a better therapeutic effect from peripheral nerve regeneration. Nerve guide conduits (NGCs) show great potential in the treatment of PNI. An increasing number of scaffold materials, including natural and synthetic polymers, have been applied to fabricate NGCs for peripheral nerve regeneration. This review focuses on recent nerve guide conduit (NGC) composite scaffold materials that are applied for nerve tissue engineering. Furthermore, the development tendency of NGCs and future areas of interest are comprehensively discussed.
周围神经损伤（PNIs）通常由创伤、免疫疾病和遗传因素引起。周围神经损伤（PNI）可能导致肢体麻木、肌肉萎缩和神经功能丧失。尽管已经提出了大量理论，但很少有治疗方法能有效导致神经功能完全恢复。自体神经移植是目前的金标准。然而，使用这种方法，所有患者中只有50%成功治愈。此外，它会对供体部位造成不可避免的损伤，而且人类可用的供体部位非常有限。组织工程已成为旨在从周围神经再生中获得更好治疗效果的研究热点。神经导管（NGCs）在PNI治疗中显示出巨大潜力。越来越多的支架材料，包括天然和合成聚合物，已被应用于制造用于周围神经再生的NGCs。本综述重点关注近期应用于神经组织工程的神经导管（NGC）复合支架材料。此外，还全面讨论了NGCs的发展趋势和未来感兴趣的领域。
