Zhang He, Ji Lu, Yang Yue, Zhang Xiaoning, Gang Yi, Bai Lunhao
Department of Orthopedic Surgery, Shengjing Hospital, China Medical University, Shenyang, China.
Department of Gynecology and Obstetrics, Shengjing Hospital, China Medical University, Shenyang, China.
Front Cell Dev Biol. 2020 Sep 30;8:560117. doi: 10.3389/fcell.2020.560117. eCollection 2020.
Epigenetics plays an important role in the pathogenesis and treatment of osteoarthritis (OA). In recent decades, HDAC family members have been associated with OA. This paper aims to describe the different role of HDACs in the pathogenesis of OA through interaction with microRNAs and the regulation of relevant signaling pathways. We found that HDACs are involved in cartilage and chondrocyte development but also play a crucial role in OA. However, the distinct HDAC mechanism in the pathogenesis and treatment of OA require further investigation. Furthermore, HDAC inhibitors (HDACi) can protect cartilage from disease, which may represent a potential therapeutic approach against OA.
表观遗传学在骨关节炎（OA）的发病机制和治疗中起着重要作用。近几十年来，组蛋白去乙酰化酶（HDAC）家族成员一直与骨关节炎相关。本文旨在通过与微小RNA相互作用以及调节相关信号通路来描述HDAC在骨关节炎发病机制中的不同作用。我们发现HDAC不仅参与软骨和软骨细胞发育，而且在骨关节炎中也起着关键作用。然而，HDAC在骨关节炎发病机制和治疗中的独特机制需要进一步研究。此外，HDAC抑制剂（HDACi）可以保护软骨免受疾病侵害，这可能代表一种针对骨关节炎的潜在治疗方法。
