Eltom Khalid, Albeely Abrar, El Hussein Abdel Rahim M, Elkhidir Isam M, Enan Khalid
Department of Microbiology and Parasitology, Faculty of Medicine University of Khartoum Khartoum Sudan.
Department of Virology, Central Laboratory Ministry of Higher Education and Scientific Research Khartoum Sudan.
JGH Open. 2020 Aug 26;4(5):800-807. doi: 10.1002/jgh3.12411. eCollection 2020 Oct.
In its occult form, hepatitis B virus infection can only be detected using molecular techniques such as polymerase chain reaction, increasing the cost of the screening process. Certain population subgroups are considered to have a higher risk of transmission and reactivation of occult hepatitis B virus infection (OBI). This review aims to estimate the prevalence of OBI among these high-risk groups in Sudan. It was conducted under the PRISMA guidelines, targeting the literature available in MEDLINE/PubMed, ScienceDirect, Google Scholar, and Cochrane Library databases. Full-text articles published in the last 10 years that provide prevalence estimates of OBI in Sudan were examined for fulfillment of eligibility criteria. Quality assessment of selected articles was performed using the critical appraisal tool reported by Munn . Publication bias was assessed by visual examination of the funnel plot. Meta-analysis using the random-effects model with 95% confidence interval was used to calculate the overall and subgroup pooled prevalence of OBI. Literature search yielded a total of 717 studies, of which only 11 articles fulfilled all selection criteria. The overall pooled prevalence of OBI was found to be 15.51%, with a high level of heterogeneity. Subgroup analysis demonstrated a prevalence of 16.48% among blood donors, 13.36% among hemodialysis patients, and 12.59% among febrile patients. Evidence for possible publication bias was detected. This review provides crucial evidence for health authorities in Sudan, outlining the necessity for re-evaluation of the current screening strategies, especially among these high-risk groups.
在隐匿型感染中，乙型肝炎病毒感染只能通过聚合酶链反应等分子技术检测到，这增加了筛查过程的成本。某些人群亚组被认为隐匿性乙型肝炎病毒感染（OBI）的传播和再激活风险较高。本综述旨在评估苏丹这些高危人群中OBI的患病率。该综述是根据PRISMA指南进行的，目标是MEDLINE/PubMed、ScienceDirect、谷歌学术和Cochrane图书馆数据库中的文献。对过去10年发表的提供苏丹OBI患病率估计的全文文章进行了资格标准的审查。使用Munn报告的批判性评估工具对所选文章进行质量评估。通过漏斗图的视觉检查评估发表偏倚。使用95%置信区间的随机效应模型进行荟萃分析，以计算OBI的总体和亚组合并患病率。文献检索共获得717项研究，其中只有11篇文章符合所有选择标准。发现OBI的总体合并患病率为15.51%，异质性较高。亚组分析显示，献血者中的患病率为16.48%，血液透析患者中的患病率为13.36%，发热患者中的患病率为12.59%。检测到可能存在发表偏倚的证据。本综述为苏丹的卫生当局提供了关键证据，概述了重新评估当前筛查策略的必要性，尤其是在这些高危人群中。
