性别对体重指数与上消化道症状频率之间关联的影响。

Influence of sex on the association between body mass index and frequency of upper gastrointestinal symptoms.

作者信息

Ogisu Kyohei, Masuda Atsuhiro, Fujita Tsuyoshi, Yamazaki Yukinao, Kobayashi Masao, Terao Shuichi, Sanuki Tsuyoshi, Okada Akihiko, Adachi Masayasu, Arisaka Yoshifumi, Miyazaki Haruka, Yoshinaka Hayato, Kutsumi Hiromu, Umegaki Eiji, Kodama Yuzo

机构信息

Division of Gastroenterology, Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan.

Department of Gastroenterology Nissay Hospital Osaka Japan.

出版信息

JGH Open. 2020 Jun 5;4(5):937-944. doi: 10.1002/jgh3.12368. eCollection 2020 Oct.

DOI:10.1002/jgh3.12368

PMID:33102767

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7578286/

Abstract

BACKGROUND AND AIM

Upper gastrointestinal symptoms (UGSs), including reflux and dyspeptic symptoms (postprandial distress syndrome [PDS] and epigastric pain syndrome [EPS]), affect health-related quality of life. However, the influence of sex on the relationship between body mass index (BMI) and UGSs remains controversial. This study investigates the influence of sex on this association in healthy subjects.

METHODS AND RESULTS

We utilized the database of a prospective, multicenter, cohort study of 7112 subjects who underwent upper endoscopy for health screening. A multivariable logistic regression analysis was conducted to assess the association between BMI and UGSs stratified by sex, adjusting for clinical features. The influence of sex on the association between the overlapping of UGSs and BMI in symptomatic subjects was also investigated. Reflux symptoms were significantly associated with high BMI (multivariable odds ratio [OR] 1.36; 95% confidence interval [CI] 1.10-1.67, = 0.004). PDS symptoms were significantly associated with low BMI (OR 2.37; 95% CI 1.70-3.25; < 0.0001), but EPS symptoms were not associated with BMI. The association between reflux symptoms and higher BMI was limited to men (men: OR 1.40; 95% CI 1.10-1.77; = 0.005, women: = 0.40). sex did not influence the association between the presence of PDS symptoms and lower BMI. The percentage of overlapping of all three symptoms (reflux, PDS, and EPS) was higher in women than in men (19.9% [58/292] 10.5% [49/468], = 0.0002).

CONCLUSIONS

The influence of BMI on the presence of UGSs was significantly different according to sex in this large-scale cohort.

摘要

背景与目的

上消化道症状（UGSs），包括反流和消化不良症状（餐后不适综合征[PDS]和上腹痛综合征[EPS]），会影响健康相关生活质量。然而，性别对体重指数（BMI）与UGSs之间关系的影响仍存在争议。本研究调查了性别对健康受试者中这种关联的影响。

方法与结果

我们利用了一项对7112名接受上消化道内镜健康筛查受试者进行的前瞻性、多中心队列研究的数据库。进行多变量逻辑回归分析，以评估按性别分层的BMI与UGSs之间的关联，并对临床特征进行调整。还研究了性别对有症状受试者中UGSs与BMI重叠关联的影响。反流症状与高BMI显著相关（多变量优势比[OR]为1.36；95%置信区间[CI]为1.10 - 1.67，P = 0.004）。PDS症状与低BMI显著相关（OR为2.37；95%CI为1.70 - 3.25；P < 0.0001），但EPS症状与BMI无关。反流症状与较高BMI之间的关联仅限于男性（男性：OR为1.40；95%CI为1.10 - 1.77；P = 0.005，女性：P = 0.40）。性别不影响PDS症状与较低BMI之间的关联。女性中三种症状（反流、PDS和EPS）全部重叠的百分比高于男性（19.9%[58/292]对10.5%[49/468]，P = 0.0002）。