Chung Sook Hee, Lee Kwang Jae, Kim Ja Yeon, Im Seon Gyo, Kim Eunkyung, Yang Min Jae, Ryu Seo Hee
Department of Gastroenterology, Ajou University School of Medicine, Suwon, Gyeonggido, Korea.
Office of Biostatistics, Ajou University School of Medicine, Suwon, Gyeonggido, Korea.
J Neurogastroenterol Motil. 2015 Oct 1;21(4):528-36. doi: 10.5056/jnm15074.
BACKGROUND/AIMS: It remains unclear whether atrophic gastritis can affect dyspeptic symptoms. We aimed to investigate whether the extent of atrophic gastritis is associated with specific dyspeptic symptoms.
Consecutive adults in a routine health-checkup program were enrolled in the study. The extent of atrophic gastritis was classified into 3 groups based on the Kimura-Takemoto criteria; the gastritis with no or little atrophy (group A: C0), the gastritis with atrophy mainly in the antrum (group B: C1 and C2), and the gastritis with atrophy in the large area of the corpus (group C: C3 and O). Upper gastrointestinal symptoms were categorized into "typical reflux symptoms," "epigastric pain syndrome (EPS)-related symptoms," and "postprandial distress syndrome (PDS)-related symptoms."
A total of 1827 patients (1009 males, mean age 45.1 years) were included in the analysis. The subgroups of atrophic gastritis were as follows: group A (n = 1218, 66.7%), group B (n = 392, 21.4%), and group C (n = 217, 11.9%). Typical reflux, EPS-related, and PDS-related symptoms were present in 10.5%, 19.8%, and 16.2% of the subjects, respectively. PDS-related and EPS-related symptoms were significantly more prevalent in the group C of male patients and the group B of female patients, respectively, compared with other groups. PDS-related and EPS-related symptoms were independently associated with the group C in males (OR, 2.123; 95% CI, 1.090-4.136) and the group B in females (OR, 2.571; 95% CI, 1.319-5.025), respectively.
The extent of atrophic gastritis appears to affect the generation of specific dyspeptic symptoms in a gender-dependent manner.
背景/目的：萎缩性胃炎是否会影响消化不良症状尚不清楚。我们旨在研究萎缩性胃炎的程度是否与特定的消化不良症状相关。
将参加常规健康检查项目的连续成年患者纳入研究。根据木村 - 竹本标准，将萎缩性胃炎的程度分为3组；无或轻度萎缩性胃炎（A组：C0）、主要胃窦部萎缩性胃炎（B组：C1和C2）、胃体大面积萎缩性胃炎（C组：C3和O）。上消化道症状分为“典型反流症状”、“上腹痛综合征（EPS）相关症状”和“餐后不适综合征（PDS）相关症状”。
共有1827例患者（男性1009例，平均年龄45.1岁）纳入分析。萎缩性胃炎亚组如下：A组（n = 1218，66.7%）、B组（n = 392，21.4%）和C组（n = 217，11.9%）。典型反流、EPS相关和PDS相关症状分别在10.5%、19.8%和16.2%的受试者中出现。与其他组相比，男性C组和女性B组的PDS相关和EPS相关症状分别显著更常见。男性中PDS相关症状和女性中EPS相关症状分别与C组（OR，2.123；95%CI，1.090 - 4.136）和B组（OR，2.571；95%CI，1.319 - 5.025）独立相关。
萎缩性胃炎的程度似乎以性别依赖的方式影响特定消化不良症状的产生。
