Witchel Selma Feldman, Plant Tony M
Division of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh/University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224 USA.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA.
Curr Opin Endocr Metab Res. 2020 Oct;14:127-136. doi: 10.1016/j.coemr.2020.07.004. Epub 2020 Jul 16.
Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder often emerging during the peri-pubertal years concomitantly with the onset of gonadarche and adrenarche. Both gonadarche and PCOS reflect functional changes in the hypothalamic-pituitary-ovarian axis. During this transition, normal girls manifest features consistent with PCOS such as irregular menses, mild hyperandrogenism, and multi-follicular ovary morphology. Themes common to puberty and PCOS, neuroendocrine features, androgen exposure, and insulin sensitivity, will be considered to address the possibility that PCOS interferes with the normal pubertal transition.
多囊卵巢综合征（PCOS）是一种异质性家族性疾病，常在青春期前后伴随着性腺初潮和肾上腺功能初现而出现。性腺初潮和PCOS均反映下丘脑 - 垂体 - 卵巢轴的功能变化。在这一转变过程中，正常女孩会表现出与PCOS一致的特征，如月经不规律、轻度高雄激素血症和多卵泡卵巢形态。将考虑青春期和PCOS共有的主题，即神经内分泌特征、雄激素暴露和胰岛素敏感性，以探讨PCOS干扰正常青春期过渡的可能性。
