Lambert S R, Hoyt C S, Narahara M H
Department of Ophthalmology, University of California, San Francisco.
Surv Ophthalmol. 1987 Jul-Aug;32(1):1-9. doi: 10.1016/0039-6257(87)90069-5.
Optic nerve hypoplasia is an easily overlooked, nonprogressive developmental anomaly which results in a wide range of visual deficits. It is frequently associated with clinically significant central nervous system and endocrine abnormalities. Maternal substance abuse is increasingly recognized in many cases. A supranormal regression of optic nerve axons in utero, rather than a primary failure of differentiation, is proposed as the pathogenesis.
视神经发育不全是一种容易被忽视的非进行性发育异常，可导致多种视力缺陷。它常与具有临床意义的中枢神经系统和内分泌异常相关。在许多病例中，越来越多地认识到母体药物滥用与之有关。其发病机制被认为是子宫内视神经轴突超常退化，而非原发性分化失败。
