耳蜗力学：振动测量法与光学相干断层扫描技术带来的新见解
Cochlear mechanics: new insights from vibrometry and Optical Coherence Tomography.
作者信息
Olson Elizabeth S, Strimbu C Elliott
机构信息
Department of Otolaryngolgy Head and Neck Surgery, Vagelos College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032.
Department Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue,New York, NY 10027.
出版信息
Curr Opin Physiol. 2020 Dec;18:56-62. doi: 10.1016/j.cophys.2020.08.022. Epub 2020 Sep 5.
Abstract
The cochlea is a complex biological machine that transduces sound-induced mechanical vibrations to neural signals. Hair cells within the sensory tissue of the cochlea transduce vibrations into electrical signals, and exert electromechanical feedback that enhances the passive frequency separation provided by the cochlea's traveling wave mechanics; this enhancement is termed cochlear amplification. The vibration of the sensory tissue has been studied with many techniques, and the current state of the art is optical coherence tomography (OCT). The OCT technique allows for motion of intra-organ structures to be measured at many layers within the sensory tissue, at several angles and in previously under-explored species. OCT-based observations are already impacting our understanding of hair cell excitation and cochlear amplification.
摘要
耳蜗是一个复杂的生物机器，它将声音引起的机械振动转化为神经信号。耳蜗感觉组织内的毛细胞将振动转化为电信号，并施加机电反馈，增强耳蜗行波机制提供的被动频率分离；这种增强被称为耳蜗放大。人们已经用多种技术研究了感觉组织的振动，目前的技术水平是光学相干断层扫描（OCT）。OCT技术能够在感觉组织内的多个层面、几个角度以及以前未充分研究的物种中测量器官内结构的运动。基于OCT的观察已经影响了我们对毛细胞兴奋和耳蜗放大的理解。
相似文献
1
Cochlear mechanics: new insights from vibrometry and Optical Coherence Tomography.耳蜗力学：振动测量法与光学相干断层扫描技术带来的新见解
Curr Opin Physiol. 2020 Dec;18:56-62. doi: 10.1016/j.cophys.2020.08.022. Epub 2020 Sep 5.
2
Reconstruction of transverse-longitudinal vibrations in the organ of Corti complex via optical coherence tomography.利用光相干断层扫描技术重建耳蜗器官的横向-纵向振动。
J Acoust Soc Am. 2023 Feb;153(2):1347. doi: 10.1121/10.0017345.
3
Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry.应用体光学相干断层扫描和振动测量法测量完整沙鼠耳蜗中的 Corti 器官振动。
J Neurophysiol. 2018 Dec 1;120(6):2847-2857. doi: 10.1152/jn.00702.2017. Epub 2018 Oct 3.
4
Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo.光学相干断层扫描术用于测量小鼠体内柯蒂氏器中声音诱发的运动。
Methods Mol Biol. 2016;1427:449-62. doi: 10.1007/978-1-4939-3615-1_24.
5
Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea.无创体内成像揭示了小鼠耳蜗中覆膜与基底膜行波之间的差异。
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3128-33. doi: 10.1073/pnas.1500038112. Epub 2015 Mar 3.
6
Interactions between Passive and Active Vibrations in the Organ of Corti In Vitro.体外柯蒂器中被动和主动振动的相互作用。
Biophys J. 2020 Jul 21;119(2):314-325. doi: 10.1016/j.bpj.2020.06.011. Epub 2020 Jun 17.
7
Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti.体内测量的二维耳蜗微力学揭示了小鼠柯蒂氏器内的径向调谐。
J Neurosci. 2016 Aug 3;36(31):8160-73. doi: 10.1523/JNEUROSCI.1157-16.2016.
8
Organ of Corti vibrations are dominated by longitudinal motion in vivo.柯蒂器的振动在体内主要表现为纵向运动。
Commun Biol. 2022 Nov 24;5(1):1285. doi: 10.1038/s42003-022-04234-7.
9
In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography.使用谱域光学相干断层扫描技术对小鼠耳蜗顶端进行体内振动测量。
Biomed Opt Express. 2013 Feb 1;4(2):230-40. doi: 10.1364/BOE.4.00230. Epub 2013 Jan 15.
10
Time-domain analysis of a three-dimensional numerical model of the human spiral cochlea at medium intensity.中强度下人类螺旋耳蜗三维数值模型的时域分析。
Comput Biol Med. 2021 Sep;136:104756. doi: 10.1016/j.compbiomed.2021.104756. Epub 2021 Aug 8.
引用本文的文献
1
Hair Cells in the Cochlea Must Tune Resonant Modes to the Edge of Instability without Destabilizing Collective Modes.耳蜗中的毛细胞必须将共振模式调谐到不稳定边缘，同时又不破坏集体模式的稳定性。
PRX Life. 2025 Jan-Mar;3(1). doi: 10.1103/prxlife.3.013001. Epub 2025 Jan 2.
2
Imaging the human cochlea using 1.3-m and 1.7-m optical coherence tomography.使用1.3米和1.7米光学相干断层扫描技术对人类耳蜗进行成像。
J Biomed Opt. 2025 Apr;30(4):046007. doi: 10.1117/1.JBO.30.4.046007. Epub 2025 Apr 17.
3
Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography.可视化耳蜗柯蒂氏器内的运动并用光学相干断层扫描技术阐明耳蜗力学。
Hear Res. 2025 Jan;455:109154. doi: 10.1016/j.heares.2024.109154. Epub 2024 Nov 27.
4
On the phase consistency of apical organ of Corti vibrations.关于柯蒂氏器顶端器官振动的相位一致性
Hear Res. 2024 Dec;454:109137. doi: 10.1016/j.heares.2024.109137. Epub 2024 Oct 28.
5
Hair cells in the cochlea must tune resonant modes to the edge of instability without destabilizing collective modes.耳蜗中的毛细胞必须将共振模式调整到不稳定边缘，同时又不会破坏集体模式的稳定性。
bioRxiv. 2024 Jul 23:2024.07.19.604330. doi: 10.1101/2024.07.19.604330.
6
The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes.内耳自噬在基础条件和与耳鸣相关综合征中的相关性。
Int J Mol Sci. 2023 Nov 23;24(23):16664. doi: 10.3390/ijms242316664.
7
Linear mixed-effect modeling of organ of Corti vibratory tuning curves.耳蜗振动调谐曲线器官的线性混合效应建模。
Hear Res. 2023 Aug;435:108820. doi: 10.1016/j.heares.2023.108820. Epub 2023 Jun 1.
8
The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.非凡的外毛细胞：纪念 W. E. 布朗内尔研讨会论文集。
J Assoc Res Otolaryngol. 2023 Apr;24(2):117-127. doi: 10.1007/s10162-022-00852-4. Epub 2023 Jan 17.
9
Sound Induced Vibrations Deform the Organ of Corti Complex in the Low-Frequency Apical Region of the Gerbil Cochlea for Normal Hearing : Sound Induced Vibrations Deform the Organ of Corti Complex.声致振动使正常听力下沙鼠耳蜗顶区低频段的柯蒂氏器复合体发生形变：声致振动使柯蒂氏器复合体发生形变。
J Assoc Res Otolaryngol. 2022 Oct;23(5):579-591. doi: 10.1007/s10162-022-00856-0. Epub 2022 Jul 7.
10
Automated classification of otitis media with OCT: augmenting pediatric image datasets with gold-standard animal model data.使用光学相干断层扫描（OCT）对中耳炎进行自动分类：用金标准动物模型数据扩充儿科图像数据集。
Biomed Opt Express. 2022 May 26;13(6):3601-3614. doi: 10.1364/BOE.453536. eCollection 2022 Jun 1.
本文引用的文献
1
Interactions between Passive and Active Vibrations in the Organ of Corti In Vitro.体外柯蒂器中被动和主动振动的相互作用。
Biophys J. 2020 Jul 21;119(2):314-325. doi: 10.1016/j.bpj.2020.06.011. Epub 2020 Jun 17.
2
The frequency limit of outer hair cell motility measured in vivo.体内测量外毛细胞运动的频率极限。
Elife. 2019 Sep 24;8:e47667. doi: 10.7554/eLife.47667.
3
Nonlinearity and amplification in cochlear responses to single and multi-tone stimuli.耳蜗对单音和多音刺激反应中的非线性与放大作用。
Hear Res. 2019 Jun;377:271-281. doi: 10.1016/j.heares.2019.04.001. Epub 2019 Apr 11.
4
LMO7 deficiency reveals the significance of the cuticular plate for hearing function.LMO7 缺失揭示了表皮板对于听力功能的重要性。
Nat Commun. 2019 Mar 8;10(1):1117. doi: 10.1038/s41467-019-09074-4.
5
Scanning optical coherence tomography probe for in vivo imaging and displacement measurements in the cochlea.用于耳蜗体内成像和位移测量的扫描光学相干断层扫描探头。
Biomed Opt Express. 2019 Feb 1;10(2):1032-1043. doi: 10.1364/BOE.10.001032.
6
A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction.一堆机制：内耳毛细胞的机械转导。
Trends Neurosci. 2019 Mar;42(3):221-236. doi: 10.1016/j.tins.2018.12.006. Epub 2019 Jan 17.
7
Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces.沿小鼠耳蜗的行波放大和抑制：外毛细胞产生力的纵向耦合空间变化的证据。
J Neurosci. 2019 Mar 6;39(10):1805-1816. doi: 10.1523/JNEUROSCI.2608-18.2019. Epub 2019 Jan 16.
8
Unusual mechanical processing of sounds at the apex of the Guinea pig cochlea.豚鼠耳蜗顶端不寻常的声音机械加工。
Hear Res. 2018 Dec;370:84-93. doi: 10.1016/j.heares.2018.09.009. Epub 2018 Oct 2.
9
Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry.应用体光学相干断层扫描和振动测量法测量完整沙鼠耳蜗中的 Corti 器官振动。
J Neurophysiol. 2018 Dec 1;120(6):2847-2857. doi: 10.1152/jn.00702.2017. Epub 2018 Oct 3.
10
Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae.活体沙鼠耳蜗网状层和基底膜振动的时间。
Elife. 2018 Sep 5;7:e37625. doi: 10.7554/eLife.37625.
Zotero 插件