中国百岁老人中该基因的等位基因分布。

Allelic distribution of gene in Chinese centenarians.

作者信息

Zhu Ying, Liang Yu, Khan Abdul Haseeb, Dong Minghua, Wan Yiqi, Sun Zhichao, Zeng Yi, Nie Chao, Tian Xiao-Li

机构信息

Human Aging Research Institute (HARI) School of Life Science, and Jiangxi Key Laboratory of Human Aging Nanchang University Nanchang China.

First Affiliated Hospital of Gannan Medical University Ganzhou China.

出版信息

Aging Med (Milton). 2020 Sep 11;3(3):195-204. doi: 10.1002/agm2.12122. eCollection 2020 Sep.

DOI:10.1002/agm2.12122

PMID:33103040

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7574633/

Abstract

OBJECTIVE

Human ABO blood groups are determined by the alleles , , and ( and ) of the gene and have been linked to the risks for cardiovascular diseases and cancers that affect lifespan.We examined the genetic associations of the gene and blood groups with longevity.

METHODS

We inspected the frequencies of the , , , and alleles in a large Chinese centenarian population (n = 2201) and in middle-aged controls (n = 2330). The single nucleotide polymorphisms were selected as allele (rs507666), (rs8176743, rs8176746, and rs8176749), (rs687289), and (rs688976, rs549446, and rs512770).

RESULTS

Supported by allelic and genotypic association studies, the frequencies of blood types A, B, O, and AB in centenarian versus control participants were not statistically different: 0.2821 versus 0.2781 (χ = 0.09, = 0.76), 0.2867 versus 0.3060 (χ = 2.03, = 0.15), 0.3380 versus 0.3159 (χ = 2.52, = 0.11), and 0.0859 versus 0.0910 (χ = 0.37, = 0.54), respectively. Sex had little effect on these distributions.

CONCLUSION

Integrated with other previous reports, we conclude from this large Chinese cohort that genetic variants of the gene and blood groups are not associated with longevity.

摘要

目的

人类ABO血型由ABO基因的等位基因A、B和O（A和B为共显性）决定，并且与影响寿命的心血管疾病和癌症风险相关联。我们研究了ABO基因和血型与长寿之间的遗传关联。

方法

我们检测了一个庞大的中国百岁老人群体（n = 2201）和中年对照组（n = 2330）中A、B、O和AB等位基因的频率。选择单核苷酸多态性作为A等位基因（rs507666）、B等位基因（rs8176743、rs8176746和rs8176749）、O等位基因（rs687289）以及AB等位基因（rs688976、rs549446和rs512770）。

结果

在等位基因和基因型关联研究的支持下，百岁老人与对照参与者中A型、B型、O型和AB型血的频率无统计学差异：分别为0.2821对0.2781（χ² = 0.09，P = 0.76）、0.2867对0.3060（χ² = 2.03，P = 0.15）、0.3380对0.3159（χ² = 2.52，P = 0.11）以及0.08�9对0.0910（χ² = 0.37，P = 0.54）。性别对这些分布影响很小。