School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom.
J Org Chem. 2020 Dec 18;85(24):15801-15826. doi: 10.1021/acs.joc.0c02045. Epub 2020 Oct 26.
The stereoselective synthesis of oligosaccharides remains one of the biggest challenges in carbohydrate chemistry. Many factors, including reaction conditions and the type of glycosyl donor and acceptor used, can affect the outcome of glycosylation reactions. In this Perspective, we discuss methods aimed to control the reactivity and stereoselectivity of glycosylation reactions using conformationally constrained glycosyl donors, with a focus on more recently developed chemistry.
寡糖的立体选择性合成仍然是碳水化合物化学中的最大挑战之一。许多因素，包括反应条件以及使用的糖基供体和受体的类型，都可能影响糖基化反应的结果。在本观点中，我们讨论了使用构象受限制的糖基供体控制糖基化反应的反应性和立体选择性的方法，重点介绍了最近开发的化学。
