Wang Juan, Zhang Ze-Kun, Jiang Fang-Fang, Qi Bo-Wen, Ding Ning, Hnin Saw Yu Yu, Liu Xiao, Li Jun, Wang Xiao-Hui, Tu Peng-Fei, Abe Ikuro, Morita Hiroyuki, Shi She-Po
Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Institute of Natural Medicine, University of Toyama, Sugitani-2630, Toyama 930-0194, Japan.
Org Lett. 2020 Nov 6;22(21):8725-8729. doi: 10.1021/acs.orglett.0c03339. Epub 2020 Oct 26.
Pelletierine, a proposed building block of alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ-piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from and , respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A.
石榴皮碱是一种生物碱（LAs）的潜在构建模块，已证明它是通过由分别从[具体来源1]和[具体来源2]中鉴定出的两种新型III型聚酮合酶（HsPKS4和PcPKS1）产生的Δ-哌啶和3-氧代戊二酸的非酶促类曼尼希缩合反应合成的。这些发现为进一步了解石杉碱甲等LAs的生物合成提供了新的见解。
