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Targeting -Mutant Non-Small-Cell Lung Cancer: One Mutation at a Time, With a Focus on Mutations.

作者信息

Burns Timothy F, Borghaei Hossein, Ramalingam Suresh S, Mok Tony S, Peters Solange

机构信息

University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, PA.

Fox Chase Cancer Center, Philadelphia, PA.

出版信息

J Clin Oncol. 2020 Dec 10;38(35):4208-4218. doi: 10.1200/JCO.20.00744. Epub 2020 Oct 26.

DOI:10.1200/JCO.20.00744
PMID:33104438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7723684/
Abstract
摘要

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Ann Oncol. 2020 Aug;31(8):1056-1064. doi: 10.1016/j.annonc.2020.04.478. Epub 2020 May 11.
2
Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS-mutant lung cancer.吡非尼酮通过阻断 STAT3 导致 KRAS 突变型肺癌的代谢致死。
Biochem Pharmacol. 2020 Jul;177:113960. doi: 10.1016/j.bcp.2020.113960. Epub 2020 Apr 13.
3
Resistance looms for KRAS inhibitors.KRAS抑制剂面临耐药问题。
Nat Med. 2020 Feb;26(2):169-170. doi: 10.1038/s41591-020-0765-z.
4
Mutant KRAS at the Heart of Tumor Immune Evasion.KRAS 突变在肿瘤免疫逃逸中的核心作用。
Immunity. 2020 Jan 14;52(1):14-16. doi: 10.1016/j.immuni.2019.12.013.
5
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition.快速非均匀适应构象特异性 KRAS(G12C)抑制。
Nature. 2020 Jan;577(7790):421-425. doi: 10.1038/s41586-019-1884-x. Epub 2020 Jan 8.
6
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma.抑制 SLC7A11/谷胱甘肽轴导致 KRAS 突变型肺腺癌的合成致死。
J Clin Invest. 2020 Apr 1;130(4):1752-1766. doi: 10.1172/JCI124049.
7
Discovery of a Covalent Inhibitor of KRAS (AMG 510) for the Treatment of Solid Tumors.发现 KRAS(AMG 510)共价抑制剂用于治疗实体瘤。
J Med Chem. 2020 Jan 9;63(1):52-65. doi: 10.1021/acs.jmedchem.9b01180. Epub 2019 Dec 24.
8
Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRAS Inhibition.垂直通路抑制克服 KRAS 抑制的适应性反馈抵抗。
Clin Cancer Res. 2020 Apr 1;26(7):1633-1643. doi: 10.1158/1078-0432.CCR-19-3523. Epub 2019 Nov 27.
9
Overall Survival with Osimertinib in Untreated, -Mutated Advanced NSCLC.奥希替尼治疗未经治、-突变型晚期 NSCLC 的总生存期。
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Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer.曾接受治疗的晚期 KRAS 突变型非小细胞肺癌中黏着斑激酶抑制剂 defactinib(VS-6063)的 2 期研究。
Lung Cancer. 2020 Jan;139:60-67. doi: 10.1016/j.lungcan.2019.10.033. Epub 2019 Nov 4.