Kobayashi A, Suzuki Y
Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan.
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 May;264(3-4):312-8. doi: 10.1016/s0176-6724(87)80049-4.
The immunosuppression elicited by Toxoplasma infection was proved to be due to suppressor macrophages. The induction of the suppressor macrophages are regulated by both H-2-linked and -nonlinked genes. The suppressor macrophages affect the proliferating step of lymphocytes, inhibiting them to reduce helper T cells, plasma cells and memory T- and B cells. The suppressive effect is via close contact of suppressor macrophages with lymphocytes, and not mediated by prostaglandins or H2O2. The more suppressive strain of mouse had heavier parasite burden than non-suppressive mouse strain. The patterns of induction of suppressor cells by various parasitic infections were compared and discussed.
弓形虫感染引发的免疫抑制被证明是由于抑制性巨噬细胞所致。抑制性巨噬细胞的诱导受H - 2连锁基因和非连锁基因的调控。抑制性巨噬细胞影响淋巴细胞的增殖步骤，抑制它们以减少辅助性T细胞、浆细胞以及记忆性T细胞和B细胞。这种抑制作用是通过抑制性巨噬细胞与淋巴细胞的紧密接触实现的，而非由前列腺素或过氧化氢介导。具有更强抑制作用的小鼠品系比无抑制作用的小鼠品系寄生虫负荷更重。对各种寄生虫感染诱导抑制性细胞的模式进行了比较和讨论。
