Department of Medicine, School of Medicine, University of California, San Diego UCSD, 9500 Gilman Dr. MC 0663, La Jolla, CA, 92093-0663, USA.
Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Curr Rheumatol Rep. 2020 Oct 26;22(12):87. doi: 10.1007/s11926-020-00962-z.
Synovial inflammation is characteristic of inflammatory chronic arthropathies and can cause progressive articular damage, chronic pain, and functional loss. Scientific research has increasingly focused on investigating anti-inflammatory micronutrients present in fruits, vegetables, spices, seeds, tea, and wine. This review aims to examine the anti-inflammatory effect of polyphenols (phytonutrients present in plants) and other micronutrients described in randomized clinical trials conducted in patients with chronic inflammatory arthropathies.
There is an increasing evidence that differences in micronutrient intake might play an essential role in pathogenesis, therapeutic response, and remission of synovitis. Randomized clinical trials with specific micronutrient- or nutrient-enriched food intake show improvement of symptoms and modulation of both pro- and anti-inflammatory mediators. We found convincing evidence of the anti-inflammatory effect of several micronutrients in arthritis symptoms and inflammation. Although in clinical practice nutritional recommendations to patients with chronic joint inflammation are not consistently prescribed, the addition of these nutrients to day-to-day eating habits could potentially change the natural history of inflammatory arthritis. Future research is needed for a consensus on the specific nutritional recommendations for patients with chronic synovial inflammation.
滑膜炎症是炎症性慢性关节病的特征，可导致进行性关节损伤、慢性疼痛和功能丧失。科学研究越来越关注调查存在于水果、蔬菜、香料、种子、茶和酒中的抗炎微量营养素。本综述旨在研究多酚（植物中存在的植物营养素）和其他在慢性炎症性关节病患者中进行的随机临床试验中描述的微量营养素的抗炎作用。
越来越多的证据表明，微量营养素摄入的差异可能在发病机制、治疗反应和滑膜炎缓解中起重要作用。具有特定微量营养素或富含营养的食物摄入的随机临床试验显示症状改善和促炎和抗炎介质的调节。我们发现了几种微量营养素在关节炎症状和炎症中具有抗炎作用的确凿证据。尽管在临床实践中，对慢性关节炎症患者的营养建议并非一致开具，但将这些营养素添加到日常饮食习惯中可能会改变炎症性关节炎的自然病程。需要进一步的研究来就慢性滑膜炎症患者的具体营养建议达成共识。
