茶摄入与类风湿关节炎和系统性红斑狼疮风险之间关系的检测：一项孟德尔随机化研究。
Testing relationship between tea intake and the risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study.
机构信息
Department of Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Clinical Laboratory Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
出版信息
Adv Rheumatol. 2023 Mar 10;63(1):10. doi: 10.1186/s42358-023-00290-7.
BACKGROUND
We performed Mendelian randomization (MR) to assess the causal effect of tea intake on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
METHODS
Genetic instruments for tea intake were obtained from a large genome-wide association study (GWAS) dataset of the UK Biobank. Genetic association estimates for RA (6236 cases and 147,221 controls) and SLE (538 cases and 213,145 controls) were obtained from the FinnGen study through the IEU GWAS database.
RESULTS
MR analyses using the inverse-variance weighted method showed that tea intake was not associated with risk of RA [odds ratio (OR) per standard deviation increment in genetically predicted tea intake = 0.997, 95% confidence interval (CI) 0.658-1.511] and SLE (OR per standard deviation increment in genetically predicted tea intake = 0.961, 95% CI 0.299-3.092). Weighted median, weighted mode, MR-Egger, leave-one-out and multivariable MR controlling for several confounding factors including current tobacco smoking, coffee intake, and alcoholic drinks per week yielded completely consistent results. No evidence of heterogeneity and pleiotropy was found.
CONCLUSION
Our MR study did not suggest a causal effect of genetically predicted tea intake on RA and SLE.
背景
我们进行了孟德尔随机化（MR）分析，以评估饮茶对类风湿关节炎（RA）和系统性红斑狼疮（SLE）的因果效应。
方法
饮茶的遗传工具来自英国生物库的一项大型全基因组关联研究（GWAS）数据集。通过 IEU GWAS 数据库从芬兰遗传研究（FinnGen study）中获得了 RA（6236 例病例和 147221 例对照）和 SLE（538 例病例和 213145 例对照）的遗传关联估计值。
结果
使用逆方差加权法进行的 MR 分析表明，饮茶与 RA 风险无关[遗传预测饮茶量每标准偏差增加的比值比（OR）=0.997，95%置信区间（CI）0.658-1.511]和 SLE（遗传预测饮茶量每标准偏差增加的比值比（OR）=0.961，95%置信区间（CI）0.299-3.092）。加权中位数、加权众数、MR-Egger、逐一剔除和多变量 MR 控制了包括当前吸烟、咖啡摄入量和每周饮酒量在内的几个混杂因素，结果完全一致。未发现异质性和多效性的证据。
结论
我们的 MR 研究表明，遗传预测的饮茶量与 RA 和 SLE 之间没有因果关系。
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