Department of Gastroenterology, Sandwell & West Birmingham Hospitals NHS Trust, West Bromwich, UK.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Am J Gastroenterol. 2021 Feb 1;116(2):416-419. doi: 10.14309/ajg.0000000000001006.
Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions.
This is a UK cohort study of 2,593 subjects with achalasia matched to 10,402 controls.
At diagnosis, achalasia was associated with autoimmune conditions (odds ratio 1.39; 95% confidence interval 1.02-1.90) and atopic conditions (1.40; 1.00-1.95) in those aged younger than 40 years.
Our findings support an autoimmune etiology in achalasia but also suggest a possible atopic etiology in younger subjects.
病例报告描述了一些具有贲门失弛缓症特征的个体随后被诊断为嗜酸性食管炎（一种特应性疾病）。我们已经研究了贲门失弛缓症与特应性和自身免疫性疾病之间的关联。
这是一项针对 2593 名贲门失弛缓症患者的英国队列研究，他们与 10402 名对照者相匹配。
在年龄小于 40 岁的患者中，贲门失弛缓症与自身免疫性疾病（比值比 1.39；95%置信区间 1.02-1.90）和特应性疾病（1.40；1.00-1.95）相关。
我们的研究结果支持贲门失弛缓症的自身免疫病因，但也提示年轻患者中可能存在特应性病因。
