Department of Gastroenterology, Lyell McEwin Hospital, Haydown Road, Elizabeth Vale, SA, 5031, Australia.
Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.
Dig Dis Sci. 2022 Apr;67(4):1101-1115. doi: 10.1007/s10620-022-07419-6. Epub 2022 Mar 1.
Eosinophilic esophagitis (EoE) is a leading cause of food bolus impaction in children and adults. The mechanism of dysphagia in EoE, particularly non-obstructive dysphagia, remains incompletely understood. While fibrostenotic processes appear to be critical in the development of dysphagia, somatosensory dysfunction and dysmotility also contribute. This review considers potential mechanisms of dysphagia and evaluates the utility of current and future treatment strategies in this context.
嗜酸性粒细胞性食管炎 (EoE) 是儿童和成人食物团块嵌塞的主要原因。EoE 吞咽困难的机制，特别是非梗阻性吞咽困难，仍不完全清楚。虽然纤维性狭窄过程似乎在吞咽困难的发展中起关键作用，但躯体感觉功能障碍和运动障碍也有贡献。本文回顾了吞咽困难的潜在机制，并评估了当前和未来治疗策略在这方面的应用。
