Mehrban Alireza, Karimi Mehdi, Ahmadi Hajikolaei Fatemeh, Saghafi Mohammad Sadra, Hassanpour Adeh Aydin, Refahi Pegah, Anushiravani Amir, Mikaeli Javad
Clinical Department, Amol Campus of Medicine Mazandaran University of Medical Sciences (MazUMS) Sari Iran.
Faculty of Medicine Bogomolets National Medical University (NMU) Kyiv Ukraine.
JGH Open. 2025 Aug 11;9(8):e70197. doi: 10.1002/jgh3.70197. eCollection 2025 Aug.
Achalasia, characterized by impaired esophageal motility, presents a challenge in diagnosis and management. Emerging evidence suggests a potential association between achalasia and thyroid disorders (TD). Understanding the prevalence and treatment response of achalasia in Iranian patients with TD compared to euthyroid counterparts is crucial for optimizing clinical care and informing further research efforts. This study aimed to investigate and compare the response rate to treatment in euthyroid and TD achalasia patients and to determine the prevalence rate of autoimmune TD in individuals with achalasia.
This cross-sectional study was conducted on 393 achalasia patients. Initially, the patients underwent thyroid tests to identify any TD. Following these tests, they were treated for achalasia and followed up at 1, 6, and 12 months. The collected data were analyzed to assess the outcomes.
The study examined data from 393 patients with achalasia and found no statistically significant correlation between the response rate to treatment in patients with normal thyroid function and those with TD ( = 0.176). Of all the participants, 292 (74.3%) underwent anti-TPO testing, revealing that 60 patients (20.5%) had autoimmune thyroiditis. The analysis showed a notable link between autoimmune thyroiditis and the patients' age ( = 0.024).
Achalasia is linked to various TD, including hyperthyroidism, hypothyroidism, and thyroid nodular diseases. Patients with autoimmune TD and esophageal issues should undergo a thorough examination, especially for excessive weight loss. Autoimmune diseases may contribute to inflammation in the esophageal myenteric plexus.
贲门失弛缓症以食管动力障碍为特征，在诊断和治疗方面具有挑战性。新出现的证据表明贲门失弛缓症与甲状腺疾病（TD）之间可能存在关联。了解伊朗甲状腺疾病患者与甲状腺功能正常的患者相比，贲门失弛缓症的患病率和治疗反应，对于优化临床护理和为进一步的研究工作提供信息至关重要。本研究旨在调查和比较甲状腺功能正常和甲状腺疾病患者贲门失弛缓症的治疗反应率，并确定贲门失弛缓症患者自身免疫性甲状腺疾病的患病率。
本横断面研究对393例贲门失弛缓症患者进行。最初，患者接受甲状腺检查以确定是否存在任何甲状腺疾病。在这些检查之后，他们接受贲门失弛缓症治疗，并在1、6和12个月时进行随访。对收集的数据进行分析以评估结果。
该研究检查了393例贲门失弛缓症患者的数据，发现甲状腺功能正常的患者和甲状腺疾病患者的治疗反应率之间没有统计学上的显著相关性（=0.176）。在所有参与者中，292例（74.3%）接受了抗甲状腺过氧化物酶检测，结果显示60例患者（20.5%）患有自身免疫性甲状腺炎。分析表明自身免疫性甲状腺炎与患者年龄之间存在显著关联（=0.024）。
贲门失弛缓症与各种甲状腺疾病有关，包括甲状腺功能亢进、甲状腺功能减退和甲状腺结节疾病。患有自身免疫性甲状腺疾病和食管问题的患者应进行全面检查，尤其是体重过度减轻的情况。自身免疫性疾病可能导致食管肌间神经丛炎症。
