Lin Tsu-Kung, Chen Shang-Der, Lin Kai-Jung, Chuang Yao-Chung
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Center for Mitochondrial Research and Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Antioxidants (Basel). 2020 Oct 22;9(11):1029. doi: 10.3390/antiox9111029.
Epilepsy is a common neurological disorder which affects patients physically and mentally and causes a real burden for the patient, family and society both medically and economically. Currently, more than one-third of epilepsy patients are still under unsatisfied control, even with new anticonvulsants. Other measures may be added to those with drug-resistant epilepsy. Excessive neuronal synchronization is the hallmark of epileptic activity and prolonged epileptic discharges such as in status epilepticus can lead to various cellular events and result in neuronal damage or death. Unbalanced oxidative status is one of the early cellular events and a critical factor to determine the fate of neurons in epilepsy. To counteract excessive oxidative damage through exogenous antioxidant supplements or induction of endogenous antioxidative capability may be a reasonable approach for current anticonvulsant therapy. In this article, we will introduce the critical roles of oxidative stress and further discuss the potential use of antioxidants in this devastating disease.
癫痫是一种常见的神经系统疾病，会对患者的身心造成影响，给患者本人、家庭以及社会带来医疗和经济上的沉重负担。目前，即便使用新型抗惊厥药物，仍有超过三分之一的癫痫患者病情控制不佳。对于耐药性癫痫患者，可能需要采取其他措施。神经元过度同步化是癫痫活动的标志，而长时间的癫痫放电，如癫痫持续状态，可导致各种细胞事件，并造成神经元损伤或死亡。氧化状态失衡是早期细胞事件之一，也是决定癫痫中神经元命运的关键因素。通过外源性抗氧化剂补充或诱导内源性抗氧化能力来对抗过度的氧化损伤，可能是当前抗惊厥治疗的一种合理方法。在本文中，我们将介绍氧化应激的关键作用，并进一步探讨抗氧化剂在这种毁灭性疾病中的潜在用途。
