Demirdogen Filiz, Akcay Guven
Department of Neurology, Mengücek Gazi Education and Research Hospital, Binali Yıldırım University, Erzincan, Turkey.
Department of Biophysics, Faculty of Medicine, Bolu Abant İzzet Baysal University, Bolu, Turkey.
Pflugers Arch. 2025 Mar;477(3):341-348. doi: 10.1007/s00424-024-03049-1. Epub 2024 Dec 7.
Epilepsy is a chronic neurological disease characterized by recurrent seizures caused by abnormal electrical activity in the brain. The aim of our study was to investigate the effect of tDCS on oxidative stress, Ca, glutamate, GABA, AMPAR1, and NMDAR1 levels in kindling-induced epilepsy model. Behavioral tests evaluated motor and cognitive functions, while assessing oxidative stress, Ca, glutamate, GABA, AMPAR1, and NMDAR1 levels in hippocampal tissue. tDCS stimulation therapy demonstrates a neuroprotective effect on motor and cognitive function postepilepsy. Our study reveals an increase in TOC, Ca, glutamate, GABA, AMPAR1, and NMDAR1 levels and a decline in total antioxidant capacity (TAC) following PTZ-induced seizures. However, tDCS treatment led to a significant decrease of Ca, total oxidant capacity (TOC), glutamate, GABA, AMPAR1, and NMDAR1 levels in the epilepsy cohorts, while simultaneously causing a spike in TAC levels. The study's results showed that tDCS treatment could have a therapeutic effect on oxidative stress, Ca, TOC, glutamate, GABA, AMPAR1, NMDAR1, and TAC in both acute and chronic kindling epilepsy models.
癫痫是一种慢性神经疾病，其特征是由大脑异常电活动引起的反复发作的癫痫发作。我们研究的目的是调查经颅直流电刺激（tDCS）对点燃诱导的癫痫模型中氧化应激、钙、谷氨酸、γ-氨基丁酸（GABA）、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体1（AMPAR1）和N-甲基-D-天冬氨酸受体1（NMDAR1）水平的影响。行为测试评估运动和认知功能，同时评估海马组织中的氧化应激、钙、谷氨酸、GABA、AMPAR1和NMDAR1水平。tDCS刺激疗法对癫痫后的运动和认知功能具有神经保护作用。我们的研究表明，在戊四氮（PTZ）诱导的癫痫发作后，总氧化能力（TOC）、钙、谷氨酸、GABA、AMPAR1和NMDAR1水平升高，而总抗氧化能力（TAC）下降。然而，tDCS治疗导致癫痫队列中钙、总氧化能力（TOC）、谷氨酸、GABA、AMPAR1和NMDAR1水平显著降低，同时导致TAC水平升高。研究结果表明，tDCS治疗对急性和慢性点燃癫痫模型中的氧化应激、钙、TOC、谷氨酸、GABA、AMPAR1、NMDAR1和TAC可能具有治疗作用。
