DLEU2：癌发生中的有意义长非编码 RNA。
DLEU2: A Meaningful Long Noncoding RNA in Oncogenesis.
机构信息
College of Medical Science, China Three Gorges University, Yichang 443002, China.
出版信息
Curr Pharm Des. 2021;27(20):2337-2343. doi: 10.2174/1381612826666201026150857.
BACKGROUND
Long non-coding RNA (lncRNA) with little or no coding ability has shown a variety of biological functions in cancer, including epigenetic regulation, DNA damage, regulation of microRNAs, and participation in signal transduction pathways. LncRNA can be used as an oncogene and tumor suppressor gene through transcriptional regulation in cancer. For example, the over-expressed lncRNA DLEU2 promotes the occurrence of laryngeal cancer, lung cancer, hepatocellular carcinoma, etc., and inhibits the progression of chronic lymphocytic leukemia. Deleted in Lymphocytic Leukemia 2 (DLEU2), as one of the long non-coding RNAs, was first found in chronic lymphoblastic leukemia and drawn into the progress of innumerable cancers. The molecular mechanism of DLEU2 in multiple tumors will be revealed.
METHODS
In this review, current studies on the biological functions and mechanisms of DLEU2 in tumors are summarized and analyzed; related researches are systematically retrieved and collected through PubMed.
RESULTS
DLEU2, a novel cancer-related lncRNA, has been demonstrated to be abnormally expressed in various malignant tumors, including leukemia, esophageal cancer, lung cancer, glioma, hepatocellular carcinoma, malignant pleural mesothelioma, bladder cancer, pancreatic cancer, pharynx and throat cancer, renal clear cell carcinoma, breast cancer, osteosarcoma. Besides, lncRNA DLEU2 has been shown to be involved in the process of proliferation, migration, invasion and inhibition of apoptosis of cancer cells.
CONCLUSION
Due to the biological functions and mechanisms involved in DLEU2, it may represent an available biomarker or potential therapeutic target in a variety of malignant tumors.
背景
具有很少或没有编码能力的长非编码 RNA（lncRNA）在癌症中表现出多种生物学功能，包括表观遗传调控、DNA 损伤、microRNA 调节以及参与信号转导途径。lncRNA 可以通过转录调控在癌症中作为癌基因和肿瘤抑制基因发挥作用。例如，过表达的 lncRNA DLEU2 促进了喉癌、肺癌、肝癌等的发生，并抑制了慢性淋巴细胞白血病的进展。缺失在淋巴细胞白血病 2 号（DLEU2）作为长非编码 RNA 之一，最初在慢性淋巴细胞白血病中发现，并被纳入无数癌症的进展。DLEU2 在多种肿瘤中的分子机制将被揭示。
方法
在这篇综述中，总结和分析了 DLEU2 在肿瘤中的生物学功能和机制的当前研究；通过 PubMed 系统地检索和收集相关研究。
结果
DLEU2 是一种新型的癌症相关 lncRNA，已证明在各种恶性肿瘤中异常表达，包括白血病、食管癌、肺癌、神经胶质瘤、肝癌、恶性胸膜间皮瘤、膀胱癌、胰腺癌、咽和喉癌、肾透明细胞癌、乳腺癌、骨肉瘤。此外，lncRNA DLEU2 已被证明参与癌细胞的增殖、迁移、侵袭和抑制凋亡过程。
结论
由于 DLEU2 涉及的生物学功能和机制，它可能代表多种恶性肿瘤中一种可用的生物标志物或潜在的治疗靶点。
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