Basic Medical College, Chongqing Medical University, Chongqing, China; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Basic Medical College, Chongqing Medical University, Chongqing, China.
Exp Cell Res. 2021 May 1;402(1):112551. doi: 10.1016/j.yexcr.2021.112551. Epub 2021 Mar 4.
Long noncoding RNAs (lncRNAs) are known to play a crucial role in the onset and progression of cervical cancer (CC). Here, the results of RNA microarray and RNA-sequencing dataset analysis showed that lncRNA DLEU2 was significantly upregulated in CC tissues. Clinicopathologic analysis indicated that lncRNA DLEU2 was closely related to tumor topography. Functional experiments and bioinformatics analysis revealed that lncRNA DLEU2 promoted CC cell proliferation and accelerated the cell cycle. Mechanistically, lncRNA DLEU2 promoted the progression of the cell cycle and inhibited the activity of the Notch signaling pathway by inhibiting p53 expression. Additionally, lncRNA DLEU2 probably interacted with ZFP36 Ring Finger Protein (ZFP36) to inhibit the expression of p53. In conclusion, this study revealed the function of lncRNA DLEU2 in CC tumorigenesis, suggesting new therapeutic targets in CC.
长链非编码 RNA（lncRNAs）在宫颈癌（CC）的发生和发展中起着至关重要的作用。在这里，RNA 微阵列和 RNA 测序数据集分析的结果表明，lncRNA DLEU2 在 CC 组织中显著上调。临床病理分析表明，lncRNA DLEU2 与肿瘤的形态学密切相关。功能实验和生物信息学分析表明，lncRNA DLEU2 促进 CC 细胞增殖并加速细胞周期。机制上，lncRNA DLEU2 通过抑制 p53 表达促进细胞周期的进展并抑制 Notch 信号通路的活性。此外，lncRNA DLEU2 可能与 ZFP36 环指蛋白（ZFP36）相互作用以抑制 p53 的表达。总之，本研究揭示了 lncRNA DLEU2 在 CC 肿瘤发生中的作用，为 CC 的治疗提供了新的靶点。
