Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mod Pathol. 2021 Jan;34(Suppl 1):78-93. doi: 10.1038/s41379-020-00706-5. Epub 2020 Oct 26.
Papillary neoplasms of the breast are a heterogeneous group of epithelial tumors nearly entirely composed of papillae. Their classification rests on the characteristics of the epithelium and the presence and distribution of the myoepithelial cells along the papillae and around the tumor. Papillary neoplasms of the breast can be diagnostically challenging, especially if only core needle biopsy (CNB) material is available. This review summarizes salient morphological and immunohistochemical features, clinical presentation, and differential diagnoses of papillary neoplasms of the breast. We include a contemporary appraisal of the upgrade rate to carcinoma (invasive carcinoma and ductal carcinoma in situ [DCIS]) and atypical hyperplasias in surgical excision specimens obtained following CNB diagnosis of papilloma without atypia, and a review of the available follow-up data in cases without immediate surgical excision.
乳腺的乳头状肿瘤是一组上皮性肿瘤，几乎完全由乳头组成。它们的分类依赖于上皮的特征以及沿乳头和肿瘤周围存在和分布的肌上皮细胞。乳腺的乳头状肿瘤具有诊断挑战性，特别是如果只有核心针活检（CNB）标本可用。本综述总结了乳腺乳头状肿瘤的显著形态学和免疫组织化学特征、临床表现和鉴别诊断。我们包括对 CNB 诊断为无非典型性的乳头状瘤后在手术切除标本中升级为癌（浸润性癌和导管原位癌[DCIS]）和非典型性增生的发生率的当代评估，以及对无立即手术切除的病例的现有随访数据的回顾。
