Wang Shijing, Zhang Qingfu, Mao Xiaoyun
Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Pathology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Front Oncol. 2024 Mar 27;14:1374091. doi: 10.3389/fonc.2024.1374091. eCollection 2024.
Invasive papillary carcinoma is a rare form of breast cancer that is more likely to occur in postmenopausal women. Previous studies have been limited to case reports and small retrospective studies, leading to low awareness of this type of tumor and difficult clinical management. According to the available literature, invasive papillary carcinoma exhibits unique pathological features and biological behaviors. Invasive papillary carcinoma is mostly luminal type, with a low rate of lymph node metastasis, which underlies its favorable prognosis. The effectiveness of adjuvant therapy in reducing tumor burden and improving prognosis in patients with invasive papillary carcinoma remains uncertain. Due to the rarity of the lesion, conducting prospective clinical trials is impractical. The use of biological models, such as organoids, can help alleviate the impact of the scarcity of this condition on research. In addition, invasive papillary carcinoma is affected by specific genomic events, and more extensive studies of gene expression profiling may provide molecular-level insights to make optimal therapeutic decisions.
浸润性乳头状癌是一种罕见的乳腺癌类型，更易发生于绝经后女性。既往研究局限于病例报告和小型回顾性研究，导致对这类肿瘤的认知度较低，临床管理也存在困难。根据现有文献，浸润性乳头状癌具有独特的病理特征和生物学行为。浸润性乳头状癌多为管腔型，淋巴结转移率低，这是其预后良好的基础。辅助治疗在减轻浸润性乳头状癌患者肿瘤负担及改善预后方面的有效性仍不确定。由于该病变罕见，开展前瞻性临床试验不切实际。使用类器官等生物学模型有助于减轻这种疾病稀缺性对研究的影响。此外，浸润性乳头状癌受特定基因组事件影响，对基因表达谱进行更广泛的研究可能会提供分子水平的见解，以做出最佳治疗决策。
