Department of Lung Diseases and Tuberculosis, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Clin Respir J. 2021 Mar;15(3):310-319. doi: 10.1111/crj.13298. Epub 2020 Nov 16.
Forced oscillation technique (FOT) is becoming increasingly widespread measurement method used for assessment of lung function. In the present study, we attempted to assess FOT values in patients after lobectomy in comparison with IPF and COPD patients.
Twenty-two patients after lobectomy due to lung cancer stage I or II, 28 patients with idiopathic pulmonary fibrosis and 17 patients with chronic obstructive pulmonary disease were enrolled in the study. All patients performed spirometry (FEV , FVC, FEV /FVC, MEF , MEF , FEF , MIF ), plethysmography (R , TLC, RV, RV/TLC) and a test using the forced oscillation technique- resistance (R at 5Hz, 11Hz and 19Hz, inspiratory, expiratory and total), reactance (Xat 5Hz, 11Hz, inspiratory, expiratory and total), Fres and expiratory flow limitation (∆X). The ANOVA Kruskal-Wallis test followed by a multiple comparison test were used to evaluate the differences in oscillatory parameters between-groups.
Patients after lobectomy presented reduced X5, X11 and moderately increased R5, R11, R19, R5-19, ∆X and Fres. R 5 weresignificantly higher when compared with IPF patients (P = 0.001). In lobectomy patients R5, X5, X11, ∆X and Fres were significantly less affected when compared with patients with COPD (P < 0.05 for all values). R5-19, which reflects small airways dysfunction, occurred to be similarly elevated as in COPD patients (0.5 vs 0.6 cmH O/L/s).Abnormalities of reactance at 11Hz were observed more frequently than at 5Hz in all groups of patients.
Patients after lobectomy due to lung cancer presented FOT abnormalities, which could be caused by lung parenchymal abnormalities following recent thoracic surgery.
呼吸强迫震荡技术（FOT）是一种越来越广泛应用于评估肺功能的测量方法。本研究旨在比较肺叶切除术后患者与特发性肺纤维化（IPF）和慢性阻塞性肺疾病（COPD）患者的 FOT 值。
共纳入 22 例因肺癌 I 期或 II 期行肺叶切除术的患者、28 例特发性肺纤维化患者和 17 例 COPD 患者。所有患者均行肺量计（FEV 1 、FVC、FEV 1 /FVC、MEF 、MEF 、FEF 、MIF ）、体积描记法（R 、TLC、RV、RV/TLC）和呼吸强迫震荡技术（气道阻力[R]在 5Hz、11Hz 和 19Hz，吸气、呼气和总）、电抗（X 在 5Hz、11Hz，吸气、呼气和总）、Fres 和呼气流量受限（ΔX ）的检测。采用方差分析 Kruskal-Wallis 检验和多重比较检验来评估组间振荡参数的差异。
肺叶切除术后患者的 X 5 、X 11 降低，而 R 5 、R 11 、R 19 、R 5-19 、ΔX 和 Fres 中度增加。与 IPF 患者相比，肺叶切除术后患者的 R 5 值显著升高（P=0.001）。与 COPD 患者相比，肺叶切除术后患者的 R 5 、X 5 、X 11 、ΔX 和 Fres 受影响更小（所有 P 值均＜0.05）。5Hz 时，与 COPD 患者相比，小气道功能障碍（R 5-19 ）的升高程度相似（0.5 比 0.6 cmH 2 O/L/s）。在所有患者组中，11Hz 时电抗异常较 5Hz 更为常见。
肺叶切除术后肺癌患者的 FOT 存在异常，这可能是由于近期胸部手术后肺实质异常所致。
